MAN2B1 mannosidase alpha class 2B member 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MAN2B1provided by VGNC
Official Full Name: mannosidase alpha class 2B member 1provided by VGNC
Primary source: VGNC:VGNC:108504
See related: BGD:BT11936; Ensembl:ENSBTAG00000006241
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MANB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (12838426..12853764)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a previously undetected mechanism of low-pH activation and a role in lysosomal transport
Title: The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation.

Submit: New GeneRIF Correction

General gene information

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Markers

MANB-9/7 (e-PCR)
- UniSTS:13330

MARC_7999-8000:996688236:1 (e-PCR)
- UniSTS:269875

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mannose metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lysosomal alpha-mannosidase

Names: laman; lysosomal acid alpha-mannosidase; mannosidase alpha-B; mannosidase, alpha B, lysosomal

NP_776986.2

EC 3.2.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174561.2 → NP_776986.2 lysosomal alpha-mannosidase precursor

See identical proteins and their annotated locations for NP_776986.2

Status: PROVISIONAL

Source sequence(s)

L31373

UniProtKB/TrEMBL

A0A452DI46

Related

ENSBTAP00000064540.2, ENSBTAT00000070599.2

Conserved Domains (4) summary

PLN02701
Location:49 → 989

PLN02701; alpha-mannosidase

cd10810
Location:64 → 342

GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

smart00872
Location:389 → 467

Alpha-mann_mid; Alpha mannosidase, middle domain

pfam07748
Location:512 → 989

Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain