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SYNJ1 synaptojanin 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282087, updated on 10-Oct-2024

Summary

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Official Symbol
SYNJ1provided by VGNC
Official Full Name
synaptojanin 1provided by VGNC
Primary source
VGNC:VGNC:35527
See related
BGD:BT12152; Ensembl:ENSBTAG00000003063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SYNJ1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (2827791..2918738)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene chromosome 1 C21orf62 homolog Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene large ribosomal subunit protein eL34-like Neighboring gene cilia and flagella associated protein 298 Neighboring gene eva-1 homolog C Neighboring gene uncharacterized LOC104970779

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A synaptojanin 1 (SYNJ1) single nucleotide polymorphism not responsible for polledness in German Holstein, Limousin, Charolais and Pinzgauer cattle. Wöhlke A, et al. Anim Genet, 2010 Jun. PMID 19922587
  2. Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Sakisaka T, et al. Mol Cell Biol, 1997 Jul. PMID 9199318, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study concludes that the bSYNJ1_C3981T SNP can be ruled out as a functional mutation for polledness in German Holstein, Limousin, Charolais and Pinzgauer cattle.
    Title: A synaptojanin 1 (SYNJ1) single nucleotide polymorphism not responsible for polledness in German Holstein, Limousin, Charolais and Pinzgauer cattle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
synaptojanin-1
Names
p150
synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1
NP_776893.2
XP_005201143.2
XP_005201145.2
XP_005201148.2
XP_005201149.2
XP_005201150.2
XP_005201151.2
XP_010799193.1
XP_024847635.1
XP_024847659.1
XP_024847727.1
XP_059742812.1
XP_059742870.1
XP_059742920.1
XP_059743141.1
XP_059743164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174468.3 → NP_776893.2  synaptojanin-1

    See identical proteins and their annotated locations for NP_776893.2

    Status: VALIDATED

    Source sequence(s)
    NKLS02000001
    UniProtKB/Swiss-Prot
    O18964
    UniProtKB/TrEMBL
    F1MC12
    Related
    ENSBTAP00000003985.7, ENSBTAT00000003985.7
    Conserved Domains (4) summary
    cd09098
    Location:533 → 868
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:60 → 340
    Syja_N; SacI homology domain
    pfam08952
    Location:867 → 1008
    DUF1866; Domain of unknown function (DUF1866)
    pfam11235
    Location:1037 → 1245
    Med25_SD1; Mediator complex subunit 25 synapsin 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    2827791..2918738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005201086.4 → XP_005201143.2  synaptojanin-1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LLX8
    Conserved Domains (4) summary
    cd09098
    Location:572 → 907
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam04503
    Location:1173 → 1505
    SSDP; Single-stranded DNA binding protein, SSDP
    pfam08952
    Location:906 → 1047
    DUF1866; Domain of unknown function (DUF1866)

  2. XM_059886937.1 → XP_059742920.1  synaptojanin-1 isoform X6

  3. XM_010800891.3 → XP_010799193.1  synaptojanin-1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1LLX8
    Related
    ENSBTAP00000057627.2, ENSBTAT00000074850.2
    Conserved Domains (3) summary
    cd09098
    Location:572 → 907
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam08952
    Location:906 → 1047
    DUF1866; Domain of unknown function (DUF1866)

  4. XM_005201091.4 → XP_005201148.2  synaptojanin-1 isoform X7

    UniProtKB/TrEMBL
    A0A3Q1LLX8
    Conserved Domains (3) summary
    cd09098
    Location:572 → 907
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam08952
    Location:906 → 1047
    DUF1866; Domain of unknown function (DUF1866)

  5. XM_005201088.4 → XP_005201145.2  synaptojanin-1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LLX8
    Conserved Domains (4) summary
    cd09098
    Location:564 → 899
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam04503
    Location:1165 → 1497
    SSDP; Single-stranded DNA binding protein, SSDP
    pfam08952
    Location:898 → 1039
    DUF1866; Domain of unknown function (DUF1866)

  6. XM_005201092.4 → XP_005201149.2  synaptojanin-1 isoform X8

    UniProtKB/TrEMBL
    A0A3Q1LLX8
    Related
    ENSBTAP00000074110.2, ENSBTAT00000069919.2
    Conserved Domains (3) summary
    cd09098
    Location:564 → 899
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam08952
    Location:898 → 1039
    DUF1866; Domain of unknown function (DUF1866)

  7. XM_059886829.1 → XP_059742812.1  synaptojanin-1 isoform X2

  8. XM_059886887.1 → XP_059742870.1  synaptojanin-1 isoform X4

  9. XM_005201093.5 → XP_005201150.2  synaptojanin-1 isoform X11

    UniProtKB/Swiss-Prot
    O18964
    Conserved Domains (3) summary
    cd09098
    Location:572 → 907
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam08952
    Location:906 → 1047
    DUF1866; Domain of unknown function (DUF1866)

  10. XM_005201094.5 → XP_005201151.2  synaptojanin-1 isoform X12

    UniProtKB/Swiss-Prot
    O18964
    Conserved Domains (3) summary
    cd09098
    Location:572 → 907
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam02383
    Location:96 → 376
    Syja_N; SacI homology domain
    pfam08952
    Location:906 → 1047
    DUF1866; Domain of unknown function (DUF1866)

  11. XM_059887158.1 → XP_059743141.1  synaptojanin-1 isoform X13

  12. XM_059887181.1 → XP_059743164.1  synaptojanin-1 isoform X14

  13. XM_024991867.2 → XP_024847635.1  synaptojanin-1 isoform X9

    UniProtKB/TrEMBL
    A0A3Q1LLX8
    Conserved Domains (4) summary
    cd09098
    Location:528 → 863
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam08952
    Location:862 → 1003
    DUF1866; Domain of unknown function (DUF1866)
    cl26464
    Location:987 → 1400
    Atrophin-1; Atrophin-1 family
    cl27434
    Location:34 → 483
    Syja_N; SacI homology domain

  14. XM_024991891.2 → XP_024847659.1  synaptojanin-1 isoform X10

    UniProtKB/TrEMBL
    A0A3Q1MSN5, E1BD68
    Related
    ENSBTAP00000003984.6, ENSBTAT00000003984.6
    Conserved Domains (4) summary
    cd09098
    Location:528 → 863
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam08952
    Location:862 → 1003
    DUF1866; Domain of unknown function (DUF1866)
    cl26464
    Location:1027 → 1429
    Atrophin-1; Atrophin-1 family
    cl27434
    Location:34 → 483
    Syja_N; SacI homology domain

  15. XM_024991959.2 → XP_024847727.1  synaptojanin-1 isoform X10

    UniProtKB/TrEMBL
    A0A3Q1MSN5, E1BD68
    Conserved Domains (4) summary
    cd09098
    Location:528 → 863
    INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
    pfam08952
    Location:862 → 1003
    DUF1866; Domain of unknown function (DUF1866)
    cl26464
    Location:1027 → 1429
    Atrophin-1; Atrophin-1 family
    cl27434
    Location:34 → 483
    Syja_N; SacI homology domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18964.2 GenPept UniProtKB/Swiss-Prot:O18964

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