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RAP1A RAP1A, member of RAS oncogene family [ Bos taurus (domestic cattle) ]

Gene ID: 282031, updated on 4-Oct-2024

Summary

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Official Symbol
RAP1Aprovided by VGNC
Official Full Name
RAP1A, member of RAS oncogene familyprovided by VGNC
Primary source
VGNC:VGNC:33715
See related
BGD:BT12135; Ensembl:ENSBTAG00000050904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See RAP1A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (31588106..31676080, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100847765 Neighboring gene transfer RNA aspartic acid (anticodon AUC) Neighboring gene inka box actin regulator 2 Neighboring gene uncharacterized LOC101903375 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene adenosine A3 receptor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The molecular heterogeneity of the smg-21/Krev-1/rap1 proteins, a GTP-binding protein having the same effector domain as ras p21s, in bovine aortic smooth muscle membranes. Kawata M, et al. Oncogene, 1991 May. PMID 1646988
  2. A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization. Kawata M, et al. J Biol Chem, 1988 Dec 15. PMID 3143720
  3. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. Glading A, et al. J Cell Biol, 2007 Oct 22. PMID 17954608, Free PMC Article
  4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rap protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Rap-1A
Names
GTP-binding protein smg p21A
NP_776873.1
XP_010801456.1
XP_024840481.1
XP_059737646.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174448.5 → NP_776873.1  ras-related protein Rap-1A

    See identical proteins and their annotated locations for NP_776873.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000003
    UniProtKB/Swiss-Prot
    A4IFG1, P62833
    UniProtKB/TrEMBL
    A0AAF6Z0F2
    Related
    ENSBTAP00000062154.1, ENSBTAT00000068678.1
    Conserved Domains (1) summary
    cd04175
    Location:3 → 167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31588106..31676080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010803154.3 → XP_010801456.1  ras-related protein Rap-1A isoform X1

    See identical proteins and their annotated locations for XP_010801456.1

    UniProtKB/Swiss-Prot
    A4IFG1, P62833
    UniProtKB/TrEMBL
    A0AAF6Z0F2
    Conserved Domains (1) summary
    cd04175
    Location:3 → 167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

  2. XM_059881663.1 → XP_059737646.1  ras-related protein Rap-1A isoform X1

    UniProtKB/Swiss-Prot
    A4IFG1, P62833
    UniProtKB/TrEMBL
    A0AAF6Z0F2

  3. XM_024984713.2 → XP_024840481.1  ras-related protein Rap-1A isoform X1

    UniProtKB/Swiss-Prot
    A4IFG1, P62833
    UniProtKB/TrEMBL
    A0AAF6Z0F2
    Conserved Domains (1) summary
    cd04175
    Location:3 → 167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62833.1 GenPept UniProtKB/Swiss-Prot:P62833

Gene LinkOut

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