PLAUR plasminogen activator, urokinase receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PLAURprovided by VGNC
Official Full Name: plasminogen activator, urokinase receptorprovided by VGNC
Primary source: VGNC:VGNC:32976
See related: BGD:BT10191; Ensembl:ENSBTAG00000013125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (51865096..51878376, complement)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
Title: Expression and localization of urokinase-type plasminogen activator receptor in bovine cumulus-oocyte complexes.
uPA/uPAR binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
Title: Expression of urokinase type plasminogen activator receptor (uPAR) in the bovine oviduct: Relationship with uPA effect on oviductal epithelial cells.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Title: Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway.
These data indicated that E. coli LPS led to an increase in u-PA activity and RNA expression of u-PA and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
Title: Effect of Escherichia coli lipopolysaccharide on u-PA activity and u-PA and u-PAR RNA expression in a bovine mammary epithelial cell line.
the interaction between uPAR and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R by different mechanisms.
Title: Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

PLAUR (e-PCR)
- UniSTS:278914

MARC_1299-1300:1061556223:1 (e-PCR)
- UniSTS:267484

Gene Ontology Provided by RefSeq

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: urokinase plasminogen activator surface receptor

Names: U-PAR; uPAR

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174423.3 → NP_776848.1 urokinase plasminogen activator surface receptor precursor

See identical proteins and their annotated locations for NP_776848.1

Status: PROVISIONAL

Source sequence(s)

S70635

UniProtKB/Swiss-Prot

A5PJ83, Q05588

UniProtKB/TrEMBL

A0AAA9TUB7

Related

ENSBTAP00000017446.4, ENSBTAT00000017446.6

Conserved Domains (2) summary

smart00134
Location:209 → 294

LU; Ly-6 antigen / uPA receptor -like domain

pfam00021
Location:23 → 97

UPAR_LY6; u-PAR/Ly-6 domain