U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NR5A1 nuclear receptor subfamily 5 group A member 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281948, updated on 4-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
NR5A1provided by VGNC
Official Full Name
nuclear receptor subfamily 5 group A member 1provided by VGNC
Primary source
VGNC:VGNC:32248
See related
BGD:BT22739; Ensembl:ENSBTAG00000009017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SF-1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NR5A1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (95513838..95538616, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 7 Neighboring gene uncharacterized LOC112448837 Neighboring gene adhesion G protein-coupled receptor D2 Neighboring gene nuclear receptor subfamily 6 group A member 1 Neighboring gene uncharacterized LOC100848407 Neighboring gene microRNA mir-181a-2 Neighboring gene microRNA mir-181b-2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Influence of 4-hydroxylated polychlorinated biphenyls on the secretory function of bovine ovarian cells: role of the steroidogenic factor-1 receptor. Mlynarczuk J, et al. Anim Reprod Sci, 2015 Apr. PMID 25726440
  2. Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells. Walther N, et al. Reprod Biol Endocrinol, 2006 Dec 19. PMID 17176485, Free PMC Article
  3. Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily. Honda S, et al. J Biol Chem, 1993 Apr 5. PMID 8463279
  4. StarD7 gene expression in trophoblast cells: contribution of SF-1 and Wnt-beta-catenin signaling. Rena V, et al. Mol Endocrinol, 2011 Aug. PMID 21622533, Free PMC Article
  5. The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum. Taniguchi H, et al. Mol Reprod Dev, 2009 Sep. PMID 19455657

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that PCBs impair the secretory function of ovarian steroidogenic cells by disrupting steroidogenesis and increasing OT secretion, and the receptor SF-1 appears to be essentially involved in these processes.
    Title: Influence of 4-hydroxylated polychlorinated biphenyls on the secretory function of bovine ovarian cells: role of the steroidogenic factor-1 receptor.
  2. The SF-1 and beta-catenin pathway convergence on StarD7 expression may have important implications in the phospholipid uptake and transport, contributing to the normal trophoblast development.
    Title: StarD7 gene expression in trophoblast cells: contribution of SF-1 and Wnt-beta-catenin signaling.
  3. GATA4 and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1, NR5A2, and the other steroidogenic markers.
    Title: The expression of the nuclear receptors NR5A1 and NR5A2 and transcription factor GATA6 correlates with steroidogenic gene expression in the bovine corpus luteum.
  4. Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
    Title: Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
  5. The role of the NR5A1 activating functions AF-1 & AF-2 was studied in luteinizing bovine theca cells. The regulation of the 3 NR5A1-controlled genes CYPA11, STAR, & INSL3 apparently is not dependent on NR5A1 activating functions AF-1 or AF-2.
    Title: Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
steroidogenic factor 1
Names
STF-1
adrenal 4-binding protein
fushi tarazu factor homolog 1
steroid hormone receptor Ad4BP

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174403.2 → NP_776828.1  steroidogenic factor 1

    See identical proteins and their annotated locations for NP_776828.1

    Status: PROVISIONAL

    Source sequence(s)
    D13569
    UniProtKB/Swiss-Prot
    Q04752
    Related
    ENSBTAP00000011869.3, ENSBTAT00000011869.5
    Conserved Domains (2) summary
    cd07070
    Location:223 → 459
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    95513838..95538616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024998291.2 → XP_024854059.1  steroidogenic factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q04752
    Conserved Domains (2) summary
    cd07070
    Location:223 → 459
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

  2. XM_010810325.4 → XP_010808627.1  steroidogenic factor 1 isoform X1

    See identical proteins and their annotated locations for XP_010808627.1

    UniProtKB/Swiss-Prot
    Q04752
    Conserved Domains (2) summary
    cd07070
    Location:223 → 459
    NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
    cd07167
    Location:13 → 105
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04752.1 GenPept UniProtKB/Swiss-Prot:Q04752

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.