ITGA2 integrin subunit alpha 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ITGA2provided by VGNC
Official Full Name: integrin subunit alpha 2provided by VGNC
Primary source: VGNC:VGNC:30313
See related: BGD:BT10611; Ensembl:ENSBTAG00000019289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	20	NC_037347.1 (25972489..26081221, complement)

Chromosome 20 - NC_037347.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
Title: Matrix-specific suppression of integrin activation in shear stress signaling.
both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound
Title: A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor-glycoprotein Ib and integrin alphabeta-collagen interactions make complementary, collagen-type-specific contributions to adhesion.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin alpha-2

Names: CD49 antigen-like family member B; GPIa; VLA-2 alpha chain; VLA-2 subunit alpha; collagen receptor; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet membrane glycoprotein Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166499.1 → NP_001159971.1 integrin alpha-2 precursor

See identical proteins and their annotated locations for NP_001159971.1

Status: VALIDATED

Source sequence(s)

NKLS02000020

UniProtKB/Swiss-Prot

P53710

UniProtKB/TrEMBL

F1MBA3

Related

ENSBTAP00000025685.5, ENSBTAT00000025685.7

Conserved Domains (3) summary

smart00191
Location:549 → 602

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:171 → 351

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:647 → 1058

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

Range

25972489..26081221 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024981212.2 → XP_024836980.1 integrin alpha-2 isoform X1

UniProtKB/TrEMBL

A0A3Q1NKA4

Conserved Domains (3) summary

smart00191
Location:341 → 394

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:439 → 850

Integrin_alpha2; Integrin alpha

cl00057
Location:2 → 143

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...