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IGF2R insulin like growth factor 2 receptor [ Bos taurus (domestic cattle) ]

Gene ID: 281849, updated on 4-Oct-2024

Summary

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Official Symbol
IGF2Rprovided by VGNC
Official Full Name
insulin like growth factor 2 receptorprovided by VGNC
Primary source
VGNC:VGNC:30082
See related
BGD:BT10008; Ensembl:ENSBTAG00000002402
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CIMPR; CI-MPR
Orthologs
human mouse all
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Genomic context

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See IGF2R in Genome Data Viewer
Location:
chromosome: 9
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (96197493..96300019)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene PARN like ribonuclease domain containing exonuclease 1 Neighboring gene MAS1 proto-oncogene, G protein-coupled receptor Neighboring gene antisense IGF2R RNA noncoding Neighboring gene solute carrier family 22 member 1 Neighboring gene solute carrier family 22 member 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor. Lobel P, et al. J Biol Chem, 1988 Feb 15. PMID 2963004
  2. Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. Long JE, et al. Gene, 2007 Feb 15. PMID 17150312
  3. Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor. Reddy ST, et al. J Biol Chem, 2004 Sep 10. PMID 15252023
  4. Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves. Suteevun-Phermthai T, et al. Anim Reprod Sci, 2009 Nov. PMID 19217227
  5. The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. Olson LJ, et al. J Biol Chem, 2004 Aug 6. PMID 15169779

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice.
    Title: Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice.
  2. Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
    Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
  3. Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
    Title: Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
  4. Here we examined the transcriptome of skeletal muscle, liver, kidney, and brain of control and LOS bovine fetuses and found that different tissues within LOS fetuses have perturbations of distinct gene pathways... only a small percent of differentially expressed genes (DEGs), including the imprinted gene IGF2R, could be associated with the neighboring differentially methylated regions
    Title: Global misregulation of genes largely uncoupled to DNA methylome epimutations characterizes a congenital overgrowth syndrome.
  5. suggest that the insulin like growth factor 2 receptor(IGF2R) gene polymorphisms could be useful genetic markers for dairy production traits in cattle
    Title: Association of SNP and STR polymorphisms of insulin-like growth factor 2 receptor (IGF2R) gene with milk traits in Holstein-Friesian cows.
  6. study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles
    Title: Possible role of IGF2 receptors in regulating selection of 2 dominant follicles in cattle selected for twin ovulations and births.
  7. imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy
    Title: Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight.
  8. Increases in CYP19A1 and FSHR mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 production.
    Title: Increased abundance of aromatase and follicle stimulating hormone receptor mRNA and decreased insulin-like growth factor-2 receptor mRNA in small ovarian follicles of cattle selected for twin births.
  9. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
    Title: The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting.
  10. Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.
    Title: Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables D-mannose binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lysosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cation-independent mannose-6-phosphate receptor
Names
300 kDa mannose 6-phosphate receptor
CI Man-6-P receptor
IGF-II receptor
M6PR
MPR 300
insulin-like growth factor II receptor
insulin-like growth factor receptor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174352.2 → NP_776777.1  cation-independent mannose-6-phosphate receptor precursor

    See identical proteins and their annotated locations for NP_776777.1

    Status: PROVISIONAL

    Source sequence(s)
    AF342811
    UniProtKB/Swiss-Prot
    P08169
    UniProtKB/TrEMBL
    F1MIE6
    Related
    ENSBTAP00000037502.4, ENSBTAT00000037678.4
    Conserved Domains (3) summary
    smart00059
    Location:1906 → 1951
    FN2; Fibronectin type 2 domain
    pfam00878
    Location:1331 → 1471
    CIMR; Cation-independent mannose-6-phosphate receptor repeat
    cl39051
    Location:649 → 772
    ATG27; Autophagy-related protein 27

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    96197493..96300019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08169.2 GenPept UniProtKB/Swiss-Prot:P08169

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials