APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: APEX1provided by VGNC
Official Full Name: apurinic/apyrimidinic endodeoxyribonuclease 1provided by VGNC
Primary source: VGNC:VGNC:26011
See related: BGD:BT20555; Ensembl:ENSBTAG00000002745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: APEN; BAP1; REF-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (26670900..26673480, complement)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meiosis progression and female age affect expression profile of DNA repair APEX1 gene in bovine oocytes.
Title: Meiosis progression and donor age affect expression profile of DNA repair genes in bovine oocytes.
prediction of the 3D structure of bovine AP lyase (BAP1); models of mutants showed substitution of Arg176-->Ala leads to the loss of DNA binding whereas mutation of Asp282-->Ala and His308-->Asn leads to a decrease in the enzymatic activity.
Title: Three-dimensional structure prediction of bovine AP lyase, BAP1: prediction of interaction with DNA and alterations as a result of Arg176-->Ala, Asp282-->Ala, and His308-->Asn mutations.

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General gene information

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Markers

MARC_10337-10338:999023022:1 (e-PCR)
- UniSTS:267117

APEX1 (e-PCR)
- UniSTS:277978

APEX (e-PCR)
- UniSTS:479967

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA repair nuclease/redox regulator APEX1

Names: AP endonuclease 1; AP lyase; APEX nuclease (multifunctional DNA repair enzyme) 1; DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic endonuclease; redox factor-1

NP_788782.2

EC 3.1.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.