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ALCAM activated leukocyte cell adhesion molecule [ Bos taurus (domestic cattle) ]

Gene ID: 281614, updated on 4-Oct-2024

Summary

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Official Symbol
ALCAMprovided by VGNC
Official Full Name
activated leukocyte cell adhesion moleculeprovided by VGNC
Primary source
VGNC:VGNC:25805
See related
BGD:BT30459; Ensembl:ENSBTAG00000000088
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ALCAM in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (49930802..50162053)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC132345526 Neighboring gene Cbl proto-oncogene B Neighboring gene uncharacterized LOC132345528

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allele substitution and dominance effects of CD166/ALCAM gene polymorphisms for endoparasite resistance and test-day traits in a small cattle population using logistic regression analyses. May K, et al. Mamm Genome, 2019 Oct. PMID 31650268
  2. Tissue distribution of CD6 and CD6 ligand in cattle: expression of the CD6 ligand (CD166) in the autonomic nervous system of cattle and the human. Konno A, et al. J Leukoc Biol, 2001 Jun. PMID 11404380
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genome-wide association study inferred the chip SNP ALCAMc.73+32791A>G as a candidate for Fasciola hepatica resistance.
    Title: Allele substitution and dominance effects of CD166/ALCAM gene polymorphisms for endoparasite resistance and test-day traits in a small cattle population using logistic regression analyses.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CD166 antigen
Names
activated leucocyte cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174238.1 → NP_776663.1  CD166 antigen precursor

    See identical proteins and their annotated locations for NP_776663.1

    Status: PROVISIONAL

    Source sequence(s)
    AB039957
    UniProtKB/Swiss-Prot
    Q9BH13
    Conserved Domains (6) summary
    smart00406
    Location:38 → 113
    IGv; Immunoglobulin V-Type
    smart00410
    Location:261 → 330
    IG_like; Immunoglobulin like
    pfam08205
    Location:137 → 231
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:346 → 412
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:256 → 313
    Ig_3; Immunoglobulin domain
    cl11960
    Location:415 → 488
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49930802..50162053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059886023.1 → XP_059742006.1  CD166 antigen isoform X1

    UniProtKB/TrEMBL
    F1MHN8
    Related
    ENSBTAP00000000097.5, ENSBTAT00000000097.6

  2. XM_059886053.1 → XP_059742036.1  CD166 antigen isoform X2

    UniProtKB/TrEMBL
    A0A3Q1NA28
    Related
    ENSBTAP00000068055.2, ENSBTAT00000071366.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BH13.1 GenPept UniProtKB/Swiss-Prot:Q9BH13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials