ABCB1 ATP-dependent translocase ABCB1 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: ABCB1
Gene description: ATP-dependent translocase ABCB1
See related: BGD:BT11513; Ensembl:ENSBTAG00000005997
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MDR1
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Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (32879527..32982658)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
Title: Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
Title: An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Title: Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
Title: Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation.
ABCB1 is expressed in bovine oocytes and embryos.
Title: Improvement of the cellular quality of cryopreserved bovine blastocysts accompanied by enhancement of the ATP-binding cassette sub-family B member 1 expression.

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Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

Names: ATP binding cassette subfamily B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; bovine P-glycoprotein; multidrug resistance protein 1

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The following sections contain reference sequences that belong to a specific genome build. Explain