TUBB2B tubulin, beta 2B class IIb [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: TUBB2B
Gene description: tubulin, beta 2B class IIb
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (50489642..50492431)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the axonemal motif sequences of betaI, betaIV and betaV tubulin are essential for ciliary function.
Title: Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating.
A combination of molecular dynamics simulations and computational docking is used to identify a single high-affinity binding site on five beta-tubulin microtubule inhibitors adjacent to the exchangeable GTP site on beta-tubulin.
Title: Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin.
These data indicate that phosphorylation of tubulin by Cdk1 could be involved in the regulation of microtubule dynamics during mitosis.
Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_24019-24020:1029775248:1 (e-PCR)
- UniSTS:268828

MARC_24021-24022:1029778648:1 (e-PCR)
- UniSTS:268829

Tubb2 (e-PCR), detects polymorphism
- UniSTS:144704

RH18135 (e-PCR)
- UniSTS:19101

Tubb2 (e-PCR), detects polymorphism
- UniSTS:256696

MARC_26445-26446:1030655521:1 (e-PCR)
- UniSTS:268999

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tubulin beta-2B chain

Names: tubulin, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.