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TPM1 tropomyosin 1 [ Bos taurus (domestic cattle) ]

Gene ID: 281544, updated on 4-Oct-2024

Summary

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Official Symbol
TPM1provided by VGNC
Official Full Name
tropomyosin 1provided by VGNC
Primary source
VGNC:VGNC:106994
See related
BGD:BT10015; Ensembl:ENSBTAG00000005373
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Note: GeneIDs 100336949 and 281544 are annotated independently on Bos_taurus_UMD_3.1.1 but may be redundant loci. [04 Feb 2015]
Orthologs
human mouse all
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Genomic context

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See TPM1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (46993263..47022836, complement)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 like Neighboring gene lactamase beta Neighboring gene uncharacterized LOC132346368 Neighboring gene microRNA mir-190a Neighboring gene talin 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges. Bai F, et al. PLoS One, 2012. PMID 23077624, Free PMC Article
  2. The effect of tropomyosin on force and elementary steps of the cross-bridge cycle in reconstituted bovine myocardium. Fujita H, et al. J Physiol, 2004 Apr 15. PMID 14742733, Free PMC Article
  3. Effects of tropomyosin internal deletion Delta23Tm on isometric tension and the cross-bridge kinetics in bovine myocardium. Lu X, et al. J Physiol, 2003 Dec 1. PMID 14500764, Free PMC Article
  4. Folding properties of functional domains of tropomodulin. Kostyukova AS, et al. Biophys J, 2001 Jul. PMID 11423419, Free PMC Article
  5. The immediate effect of HCM causing actin mutants E99K and A230V on actin-Tm-myosin interaction in thin-filament reconstituted myocardium. Bai F, et al. J Mol Cell Cardiol, 2015 Feb. PMID 25451174

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The first step of hypertrophic cardiomyopathy pathogenesis with E99K is increased calcium sensitivity and decreased calcium cooperativity, which result in larger tension during partial activation to cause a diastolic problem.
    Title: The immediate effect of HCM causing actin mutants E99K and A230V on actin-Tm-myosin interaction in thin-filament reconstituted myocardium.
  2. over-inhibition of the actomyosin interaction by E40K and E54K Tm mutants leads to a decreased force-generating ability at systole, which is the main mechanism underlying the early pathogenesis of DCM.
    Title: DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges.
  3. The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles.
    Title: Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.
  4. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules
    Title: Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant.
  5. Tropomyosin is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle.
    Title: The effect of tropomyosin on force and elementary steps of the cross-bridge cycle in reconstituted bovine myocardium.
  6. Deletion of regions 2-3 in tropomyosin alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin-reconstituted myocardium.
    Title: Effects of tropomyosin internal deletion Delta23Tm on isometric tension and the cross-bridge kinetics in bovine myocardium.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tropomyosin alpha-1 chain
Names
tropomyosin 1 (alpha)
tropomyosin 1 alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013590.2 → NP_001013608.1  tropomyosin alpha-1 chain

    See identical proteins and their annotated locations for NP_001013608.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102909
    UniProtKB/Swiss-Prot
    Q5KR49
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    46993263..47022836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997253.2 → XP_024853021.1  tropomyosin alpha-1 chain isoform X9

    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  2. XM_024997259.2 → XP_024853027.1  tropomyosin alpha-1 chain isoform X13

    UniProtKB/TrEMBL
    A0AAF6ZFK7
    Related
    ENSBTAP00000042255.5, ENSBTAT00000044796.5
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  3. XM_024997256.2 → XP_024853024.1  tropomyosin alpha-1 chain isoform X11

    UniProtKB/TrEMBL
    A0AAA9TTT0
    Related
    ENSBTAP00000099946.1, ENSBTAT00000100322.1
    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  4. XM_024997260.2 → XP_024853028.1  tropomyosin alpha-1 chain isoform X14

    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  5. XM_059890209.1 → XP_059746192.1  tropomyosin alpha-1 chain isoform X21

    UniProtKB/TrEMBL
    A0A3Q1LPQ6
    Related
    ENSBTAP00000058989.2, ENSBTAT00000074743.2

  6. XM_024997246.2 → XP_024853014.1  tropomyosin alpha-1 chain isoform X2

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  7. XM_024997249.2 → XP_024853017.1  tropomyosin alpha-1 chain isoform X4

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  8. XM_059890204.1 → XP_059746187.1  tropomyosin alpha-1 chain isoform X17

  9. XM_059890206.1 → XP_059746189.1  tropomyosin alpha-1 chain isoform X19

  10. XM_059890205.1 → XP_059746188.1  tropomyosin alpha-1 chain isoform X18

  11. XM_059890207.1 → XP_059746190.1  tropomyosin alpha-1 chain isoform X20

  12. XM_024997250.2 → XP_024853018.1  tropomyosin alpha-1 chain isoform X7

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 244
    Tropomyosin

  13. XM_024997251.2 → XP_024853019.1  tropomyosin alpha-1 chain isoform X8

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 244
    Tropomyosin

  14. XM_059890212.1 → XP_059746195.1  tropomyosin alpha-1 chain isoform X24

  15. XM_059890213.1 → XP_059746196.1  tropomyosin alpha-1 chain isoform X25

  16. XM_024997257.2 → XP_024853025.1  tropomyosin alpha-1 chain isoform X12

    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  17. XM_059890214.1 → XP_059746197.1  tropomyosin alpha-1 chain isoform X26

  18. XM_024997254.2 → XP_024853022.1  tropomyosin alpha-1 chain isoform X10

    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  19. XM_059890215.1 → XP_059746198.1  tropomyosin alpha-1 chain isoform X27

  20. XM_024997244.2 → XP_024853012.1  tropomyosin alpha-1 chain isoform X1

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  21. XM_059890216.1 → XP_059746199.1  tropomyosin alpha-1 chain isoform X28

  22. XM_024997247.2 → XP_024853015.1  tropomyosin alpha-1 chain isoform X3

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  23. XM_024997255.2 → XP_024853023.1  tropomyosin alpha-1 chain isoform X15

    Conserved Domains (1) summary
    pfam00261
    Location:48 → 282
    Tropomyosin

  24. XM_059890203.1 → XP_059746186.1  tropomyosin alpha-1 chain isoform X16

  25. XM_059890211.1 → XP_059746194.1  tropomyosin alpha-1 chain isoform X23

  26. XM_059890210.1 → XP_059746193.1  tropomyosin alpha-1 chain isoform X22

  27. XM_024997245.2 → XP_024853013.1  tropomyosin alpha-1 chain isoform X5

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin

  28. XM_024997248.2 → XP_024853016.1  tropomyosin alpha-1 chain isoform X6

    Conserved Domains (1) summary
    pfam00261
    Location:12 → 246
    Tropomyosin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5KR49.1 GenPept UniProtKB/Swiss-Prot:Q5KR49

Gene LinkOut

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