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TBCD tubulin folding cofactor D [ Bos taurus (domestic cattle) ]

Gene ID: 281515, updated on 4-Oct-2024

Summary

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Official Symbol
TBCDprovided by VGNC
Official Full Name
tubulin folding cofactor Dprovided by VGNC
Primary source
VGNC:VGNC:35652
See related
BGD:BT17100; Ensembl:ENSBTAG00000015414
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See TBCD in Genome Data Viewer
Location:
chromosome: 19
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (49768459..49916763, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343104 Neighboring gene meteorin like, glial cell differentiation regulator Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 Neighboring gene microRNA mir-2344 Neighboring gene zinc finger protein 750 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene fructosamine 3 kinase Neighboring gene fructosamine 3 kinase related protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle. Cunningham LA, et al. J Biol Chem, 2008 Mar 14. PMID 18171676
  2. Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure. Shultz T, et al. FASEB J, 2008 Jan. PMID 17704193
  3. Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity. Tian G, et al. Cytoskeleton (Hoboken), 2010 Nov. PMID 20740604, Free PMC Article
  4. The alpha- and beta-tubulin folding pathways. Lewis SA, et al. Trends Cell Biol, 1997 Dec. PMID 17709011
  5. Pathway leading to correctly folded beta-tubulin. Tian G, et al. Cell, 1996 Jul 26. PMID 8706133

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tubulin-specific chaperone D
Names
beta-tubulin cofactor D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174194.2 → NP_776619.1  tubulin-specific chaperone D

    See identical proteins and their annotated locations for NP_776619.1

    Status: PROVISIONAL

    Source sequence(s)
    U61233
    UniProtKB/Swiss-Prot
    Q28205
    UniProtKB/TrEMBL
    A0A3Q1LIQ9
    Related
    ENSBTAP00000059009.2, ENSBTAT00000082949.2
    Conserved Domains (2) summary
    pfam12612
    Location:905 → 1095
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:40 → 597
    TFCD_C; Tubulin folding cofactor D C terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49768459..49916763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010816446.4 → XP_010814748.1  tubulin-specific chaperone D isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LIQ9
    Conserved Domains (2) summary
    pfam12612
    Location:917 → 1107
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:40 → 609
    TFCD_C; Tubulin folding cofactor D C terminal

  2. XM_010816445.4 → XP_010814747.1  tubulin-specific chaperone D isoform X2

    UniProtKB/TrEMBL
    A0AAA9SWC2, A0AAA9TNW7
    Related
    ENSBTAP00000090769.1, ENSBTAT00000115781.1
    Conserved Domains (2) summary
    pfam12612
    Location:905 → 1095
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:40 → 597
    TFCD_C; Tubulin folding cofactor D C terminal

  3. XM_010816444.4 → XP_010814746.1  tubulin-specific chaperone D isoform X1

    UniProtKB/TrEMBL
    A0AAA9TNW7
    Conserved Domains (3) summary
    pfam12612
    Location:917 → 1107
    TFCD_C; Tubulin folding cofactor D C terminal
    sd00044
    Location:380 → 408
    HEAT; HEAT repeat [structural motif]
    cl19887
    Location:40 → 609
    TFCD_C; Tubulin folding cofactor D C terminal

  4. XM_024979598.2 → XP_024835366.1  tubulin-specific chaperone D isoform X4

    UniProtKB/TrEMBL
    A0AAA9TNW7
    Conserved Domains (2) summary
    pfam12612
    Location:837 → 1024
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:3 → 526
    TFCD_C; Tubulin folding cofactor D C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28205.1 GenPept UniProtKB/Swiss-Prot:Q28205

Gene LinkOut

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