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NT5E 5'-nucleotidase ecto [ Bos taurus (cattle) ]

Gene ID: 281363, updated on 2-Jun-2024

Summary

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Gene symbol
NT5E
Gene description
5'-nucleotidase ecto
See related
BGD:BT11043; Ensembl:ENSBTAG00000048655
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NT5E in Genome Data Viewer
Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (63953756..64026731, complement)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin binding cytoplasmic RNA interacting protein Neighboring gene sorting nexin 14 Neighboring gene heat shock protein HSP 90-beta-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef. Komatsu T, et al. Meat Sci, 2019 Dec. PMID 31401370
  2. The ecto-5'-nucleotidase subunits in dimers are not linked by disulfide bridges but by non-covalent bonds. Martínez-Martínez A, et al. Biochim Biophys Acta, 2000 May 23. PMID 10825541
  3. Purification and cDNA cloning of bovine liver 5'-nucleotidase, a GPI-anchored protein, and its expression in COS cells. Suzuki K, et al. J Biochem, 1993 May. PMID 8340354
  4. Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus. da Silva AS, et al. Comp Immunol Microbiol Infect Dis, 2017 Apr. PMID 28504100
  5. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The degradation rate of Inosine 5'-monophosphate (IMP) in Japanese Black beef was significantly different among NT5E genotypes in the middle stage of postmortem, indicating a significant difference in the concentrations of IMP and its degradation products among NT5E genotypes
    Title: The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.
  2. study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
    Title: Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in AMP catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5'-nucleotidase
Names
5'-NT
5'-deoxynucleotidase
5'-nucleotidase, ecto (CD73)
IMP-specific 5'-nucleotidase
ecto-5'-nucleotidase
thymidylate 5'-phosphatase
NP_776554.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174129.4 → NP_776554.2  5'-nucleotidase precursor

    See identical proteins and their annotated locations for NP_776554.2

    Status: PROVISIONAL

    Source sequence(s)
    BC114093
    UniProtKB/Swiss-Prot
    Q05927, Q24K05
    UniProtKB/TrEMBL
    A0A3Q1MCG3
    Related
    ENSBTAP00000071808.1, ENSBTAT00000074100.1
    Conserved Domains (3) summary
    COG0737
    Location:14 → 532
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:29 → 310
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:339 → 507
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    63953756..64026731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05927.2 GenPept UniProtKB/Swiss-Prot:Q05927

Gene LinkOut

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Molecular Biology Databases
Research Materials