MUC1 mucin 1, cell surface associated [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MUC1provided by VGNC
Official Full Name: mucin 1, cell surface associatedprovided by VGNC
Primary source: VGNC:VGNC:59186
See related: Ensembl:ENSBTAG00000017104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: mucin
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (15427824..15432023)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.
Title: Mucin 1 and cytokines mRNA in endometrium of dairy cows with postpartum uterine disease or repeat breeding.
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.
Title: Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells.
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces
Title: Bovine Muc1 is a highly polymorphic gene encoding an extensively glycosylated mucin that binds bacteria.

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General gene information

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Gene Ontology Provided by RefSeq

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mucin-1

Names: MUC-1; mucin 1, transmembrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372018.1 → NP_001358947.1 mucin-1 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

NKLS02000003

Related

ENSBTAP00000065814.2, ENSBTAT00000072582.2

Conserved Domains (2) summary

smart00200
Location:423 → 538

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

PLN02217
Location:303 → 415

PLN02217; probable pectinesterase/pectinesterase inhibitor
NM_174115.3 → NP_776540.2 mucin-1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) retains two alternate introns in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

NKLS02000003

UniProtKB/Swiss-Prot

Q8WML4, Q95L89

Related

ENSBTAP00000064682.1, ENSBTAT00000086494.2

Conserved Domains (2) summary

smart00200
Location:363 → 478

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

PLN02217
Location:243 → 355

PLN02217; probable pectinesterase/pectinesterase inhibitor