KRT5 keratin 5 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: KRT5provided by VGNC
Official Full Name: keratin 5provided by VGNC
Primary source: VGNC:VGNC:50405
See related: BGD:BT10877; Ensembl:ENSBTAG00000038384
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (27367078..27372929)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMHC IIA may play critical roles in the early trophoblast-derived ectoplacental cone and extraembryonic ectoderm in Keratin 5-Cre transgenic mice.
Title: Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.
G to A substitution in all affected animals. This mutation leads to an amino acid change of glutamic acid to lysine in the final E (478) of the KLLEGE motif of the protein.
Title: A mutation in bovine keratin 5 causing epidermolysis bullosa simplex, transmitted by a mosaic sire.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in keratinization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in keratin filament	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: keratin, type II cytoskeletal 5

Names: CK-5; K5; cytokeratin-5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin, type II cytoskeletal 60 kDa, component III; type-II keratin Kb5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008663.1 → NP_001008663.1 keratin, type II cytoskeletal 5

See identical proteins and their annotated locations for NP_001008663.1

Status: PROVISIONAL

Source sequence(s)

AY740402

UniProtKB/Swiss-Prot

Q5XQN5

UniProtKB/TrEMBL

A5D7M6

Related

ENSBTAP00000021456.6, ENSBTAT00000021456.7

Conserved Domains (3) summary

pfam00038
Location:168 → 481

Filament; Intermediate filament protein

pfam16208
Location:16 → 165

Keratin_2_head; Keratin type II head

cl01888
Location:394 → 454

DUF883; Bacterial protein of unknown function (DUF883)