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IL15 interleukin 15 [ Bos taurus (domestic cattle) ]

Gene ID: 281248, updated on 4-Oct-2024

Summary

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Official Symbol
IL15provided by VGNC
Official Full Name
interleukin 15provided by VGNC
Primary source
VGNC:VGNC:30116
See related
BGD:BT14564; Ensembl:ENSBTAG00000018200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See IL15 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (16049324..16144642, complement)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342582 Neighboring gene inositol polyphosphate-4-phosphatase type II B Neighboring gene glutathione S-transferase A4-like Neighboring gene zinc finger protein 330 Neighboring gene regulator of nonsense transcripts 3B-like Neighboring gene ring finger protein 150

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interleukin-15 inhibits adipogenic differentiation of cattle bone marrow-derived mesenchymal stem cells via regulating the crosstalk between signal transducer and activator of transcription 5A and Akt signalling. Shi M, et al. Biochem Biophys Res Commun, 2019 Sep 17. PMID 31358322
  2. Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2. Tourkova IL, et al. J Leukoc Biol, 2002 Nov. PMID 12429727
  3. Cloning and expression of bovine interleukin-15: analysis and modulation of transcription by exogenous stimulation. Canals A, et al. J Interferon Cytokine Res, 1997 Aug. PMID 9282828
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-15 inhibited adipogenic differentiation of bone marrow-derived mesenchymal stem cells via regulating the crosstalk between STAT5A and Akt signaling pathways.
    Title: Interleukin-15 inhibits adipogenic differentiation of cattle bone marrow-derived mesenchymal stem cells via regulating the crosstalk between signal transducer and activator of transcription 5A and Akt signalling.
  2. Increased function and survival of IL-15-transduced dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2.
    Title: Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neutrophil activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-15
Names
IL-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174090.1 → NP_776515.1  interleukin-15 precursor

    See identical proteins and their annotated locations for NP_776515.1

    Status: PROVISIONAL

    Source sequence(s)
    U42433
    UniProtKB/Swiss-Prot
    Q28028
    UniProtKB/TrEMBL
    B3GDZ2
    Conserved Domains (1) summary
    pfam02372
    Location:33 → 154
    IL15; Interleukin 15

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    16049324..16144642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015475375.3 → XP_015330861.1  interleukin-15 isoform X1

    UniProtKB/Swiss-Prot
    Q28028
    UniProtKB/TrEMBL
    B3GDZ2
    Conserved Domains (1) summary
    pfam02372
    Location:33 → 154
    IL15; Interleukin 15

  2. XM_015475376.3 → XP_015330862.1  interleukin-15 isoform X1

    UniProtKB/Swiss-Prot
    Q28028
    UniProtKB/TrEMBL
    B3GDZ2
    Related
    ENSBTAP00000024226.3, ENSBTAT00000024226.5
    Conserved Domains (1) summary
    pfam02372
    Location:33 → 154
    IL15; Interleukin 15

  3. XM_005217529.5 → XP_005217586.1  interleukin-15 isoform X1

    See identical proteins and their annotated locations for XP_005217586.1

    UniProtKB/Swiss-Prot
    Q28028
    UniProtKB/TrEMBL
    B3GDZ2
    Conserved Domains (1) summary
    pfam02372
    Location:33 → 154
    IL15; Interleukin 15

RNA

  1. XR_009490943.1 RNA Sequence

  2. XR_009490942.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28028.1 GenPept UniProtKB/Swiss-Prot:Q28028

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.