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IGF2 insulin like growth factor 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281240, updated on 12-Oct-2024

Summary

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Official Symbol
IGF2provided by VGNC
Official Full Name
insulin like growth factor 2provided by VGNC
Primary source
VGNC:VGNC:30078
See related
BGD:BT11333; Ensembl:ENSBTAG00000013066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
This gene encodes a member of the insulin family of protein growth factors, which are involved in fetal development and growth. It is an imprinted gene that is expressed from the paternal allele while the maternal allele is silenced. The encoded protein is proteolytically processed to generate the mature peptide hormone, which binds to receptors of the insulin receptor family. This peptide plays a role in oocyte development and folliculogenesis in female cattle. Polymorphisms in this gene may be associated with cattle body mass. [provided by RefSeq, Dec 2018]
Orthologs
human mouse all
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Genomic context

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See IGF2 in Genome Data Viewer
Location:
chromosome: 29
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (49395153..49422472)

Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene tyrosine hydroxylase Neighboring gene insulin Neighboring gene microRNA mir-483 Neighboring gene uncharacterized LOC132344217 Neighboring gene uncharacterized LOC101902537

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA methylation in the IGF2 intragenic DMR is re-established in a sex-specific manner in bovine blastocysts after somatic cloning. Gebert C, et al. Genomics, 2009 Jul. PMID 19341790
  2. Nucleotide sequence of the central coding region of bovine erythrotropin/insulin-like growth factor II cDNA from fetal intestine and northern analysis of the major IGF II transcripts at the time of hepatic erythropoiesis. Congote LF, et al. Comp Biochem Physiol B, 1992 Sep. PMID 1280544
  3. A heparin-binding erythroid cell stimulating factor from fetal bovine serum has the N-terminal sequence of insulin-like growth factor II. Li QG, et al. Biochem Biophys Res Commun, 1990 Jan 30. PMID 2302223
  4. Linkage mapping of IGF2 on cattle chromosome 29. Goodall JJ, et al. Anim Genet, 2003 Aug. PMID 12873229
  5. Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine. Dindot SV, et al. Mamm Genome, 2004 Dec. PMID 15599555

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
    Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
  2. Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
    Title: Characterisation of the methylation pattern in the intragenic CpG island of the IGF2 gene in Bos taurus indicus cumulus cells during in vitro maturation.
  3. Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
    Title: SNP and haplotype analysis reveal IGF2 variants associated with growth traits in Chinese Qinchuan cattle.
  4. The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
    Title: Comparative analysis of the IGF2 and ZBED6 gene variants and haplotypes reveals significant effect of growth traits in cattle.
  5. Polymorphisms in the IGF2 gene are associated with cattle growth traits.
    Title: Assessment of association between variants and haplotypes of the IGF2 gene in beef cattle.
  6. The LEP, IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
    Title: Allelic gene expression imbalance of bovine IGF2, LEP and CCL2 genes in liver, kidney and pituitary.
  7. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
    Title: The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting.
  8. The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 and IGF-2) and in the jejunum (IGF-1) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
    Title: Insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) mRNA levels in relation to the gastrointestinal tract (GIT) development in newborn calves.
  9. Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
    Title: Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies.
  10. Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
    Title: Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC140034

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor II
Names
IGF-II
erythrotropin
insulin-like growth factor 2 (somatomedin A)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367627.1 → NP_001354556.1  insulin-like growth factor II preproprotein

    Status: REVIEWED

    Source sequence(s)
    NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3

  2. NM_001367628.1 → NP_001354557.1  insulin-like growth factor II preproprotein

    Status: REVIEWED

    Source sequence(s)
    NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3

  3. NM_001367629.1 → NP_001354558.1  insulin-like growth factor II preproprotein

    Status: REVIEWED

    Source sequence(s)
    NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3

  4. NM_001367630.1 → NP_001354559.1  insulin-like growth factor II preproprotein

    Status: REVIEWED

    Source sequence(s)
    EE251352, NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3

  5. NM_001367631.1 → NP_001354560.1  insulin-like growth factor II preproprotein

    Status: REVIEWED

    Source sequence(s)
    BC116039, NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3

  6. NM_001367632.1 → NP_001354561.1  insulin-like growth factor II preproprotein

    Status: REVIEWED

    Source sequence(s)
    NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3

  7. NM_174087.4 → NP_776512.2  insulin-like growth factor II preproprotein

    See identical proteins and their annotated locations for NP_776512.2

    Status: REVIEWED

    Source sequence(s)
    NKLS02000029
    UniProtKB/Swiss-Prot
    A0A5F2, P07456, Q2HJN0
    UniProtKB/TrEMBL
    B8QGI3
    Related
    ENSBTAP00000017372.5, ENSBTAT00000017372.7
    Conserved Domains (2) summary
    cd04368
    Location:28 → 91
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:112 → 166
    IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49395153..49422472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005227270.5 → XP_005227327.1  insulin-like growth factor II isoform X1

    See identical proteins and their annotated locations for XP_005227327.1

    UniProtKB/TrEMBL
    A0AAA9TF33
    Related
    ENSBTAP00000094753.1, ENSBTAT00000134412.1
    Conserved Domains (2) summary
    cd04368
    Location:84 → 147
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:168 → 222
    IGF2_C; Insulin-like growth factor II E-peptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07456.4 GenPept UniProtKB/Swiss-Prot:P07456

Gene LinkOut

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