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UBE2K ubiquitin conjugating enzyme E2 K [ Bos taurus (domestic cattle) ]

Gene ID: 281225, updated on 4-Oct-2024

Summary

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Official Symbol
UBE2Kprovided by VGNC
Official Full Name
ubiquitin conjugating enzyme E2 Kprovided by VGNC
Primary source
VGNC:VGNC:36587
See related
BGD:BT11428; Ensembl:ENSBTAG00000020175
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
LIG; HIP2; HYPG; E2-25K
Orthologs
human mouse all
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Genomic context

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See UBE2K in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (58774603..58854233)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene small integral membrane protein 14 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene PDS5 cohesin associated factor A Neighboring gene nucleosome assembly protein 1-like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Core domain mutation (S86Y) selectively inactivates polyubiquitin chain synthesis catalyzed by E2-25K. Mastrandrea LD, et al. Biochemistry, 1998 Jul 7. PMID 9657692
  2. Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element. Haldeman MT, et al. Biochemistry, 1997 Aug 26. PMID 9265633
  3. Isolation of a cDNA encoding a mammalian multiubiquitinating enzyme (E225K) and overexpression of the functional enzyme in Escherichia coli. Chen ZJ, et al. J Biol Chem, 1991 Aug 25. PMID 1714895
  4. Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2). Cook WJ, et al. J Biol Chem, 1992 Aug 15. PMID 1322903
  5. SUMO modification of the ubiquitin-conjugating enzyme E2-25K. Pichler A, et al. Nat Struct Mol Biol, 2005 Mar. PMID 15723079

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 K
Names
E2 ubiquitin-conjugating enzyme K
E2(25K)
HIP-2
huntingtin interacting protein 2
ubiquitin carrier protein
ubiquitin-conjugating enzyme E2-25 kDa
ubiquitin-conjugating enzyme E2-25K
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
ubiquitin-protein ligase
NP_776505.1
XP_024848745.1
XP_024848746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174080.2 → NP_776505.1  ubiquitin-conjugating enzyme E2 K

    See identical proteins and their annotated locations for NP_776505.1

    Status: PROVISIONAL

    Source sequence(s)
    S51016
    UniProtKB/TrEMBL
    A0AAA9S8T0
    Related
    ENSBTAP00000078565.1, ENSBTAT00000112751.1
    Conserved Domains (3) summary
    COG5078
    Location:1 → 153
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:6 → 149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cd14390
    Location:163 → 200
    UBA_II_E2_UBE2K; UBA domain of vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    58774603..58854233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024992977.2 → XP_024848745.1  ubiquitin-conjugating enzyme E2 K isoform X1

    UniProtKB/TrEMBL
    A0AAF6Z802
    Related
    ENSBTAP00000026871.6, ENSBTAT00000026871.7
    Conserved Domains (2) summary
    smart00212
    Location:22 → 103
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    cl21463
    Location:112 → 149
    UBA_like_SF; UBA domain-like superfamily

  2. XM_024992978.2 → XP_024848746.1  ubiquitin-conjugating enzyme E2 K isoform X2

    Conserved Domains (2) summary
    cl00154
    Location:1 → 51
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    cl21463
    Location:60 → 97
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61085.3 GenPept UniProtKB/Swiss-Prot:P61085

Gene LinkOut

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