GNB1 G protein subunit beta 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GNB1provided by VGNC
Official Full Name: G protein subunit beta 1provided by VGNC
Primary source: VGNC:VGNC:29457
See related: BGD:BT11474; Ensembl:ENSBTAG00000000215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HG2A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (50856295..50933401)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that a hetero-multimer complex forms between light-activated rhodopsin and light-activated heterotrimeric transducin (T-alpha-1, Gnb1, Gngt1); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.
Title: Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex.
The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain.
Title: Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-Gβ1γ2 Complex.
determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits
Title: Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma.
conclude that GNB1 constitutes over 99% of the GNbeta expressed in bovine rod outer segments and displays structural heterogeneity that is due to post-translational modification, some of which is due to phosphorylation of GNB1.
Title: Proteomic analysis of transducin beta-subunit structural heterogeneity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_4069-4070:996679334:1 (e-PCR)
- UniSTS:269317

GNB1_(5) (e-PCR)
- UniSTS:278488

PMC197251P1 (e-PCR)
- UniSTS:271850

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Names: guanine nucleotide-binding protein, beta-1 subunit; heterotrimeric guanine nucleotide-binding protein 2A; transducin beta chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175777.3 → NP_786971.2 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

See identical proteins and their annotated locations for NP_786971.2

Status: PROVISIONAL

Source sequence(s)

BC105260

UniProtKB/Swiss-Prot

P62871, Q3MHF1

UniProtKB/TrEMBL

A7E3V7

Related

ENSBTAP00000042481.1, ENSBTAT00000045065.3

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

Range

50856295..50933401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005217017.3 → XP_005217074.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

See identical proteins and their annotated locations for XP_005217074.1

UniProtKB/Swiss-Prot

P62871, Q3MHF1

UniProtKB/TrEMBL

A7E3V7

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]