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Nsun2 NOL1/NOP2/Sun domain family member 2 [ Mus musculus (house mouse) ]

Gene ID: 28114, updated on 12-Nov-2024

Summary

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Official Symbol
Nsun2provided by MGI
Official Full Name
NOL1/NOP2/Sun domain family member 2provided by MGI
Primary source
MGI:MGI:107252
See related
Ensembl:ENSMUSG00000021595 AllianceGenome:MGI:107252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Misu; D13Wsu123e
Summary
Enables mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytidine-5-)-methyltransferase activity. Involved in several processes, including RNA processing; meiotic cell cycle checkpoint signaling; and tRNA stabilization. Acts upstream of or within in utero embryonic development. Located in chromatoid body. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 24.0), testis adult (RPKM 23.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nsun2 in Genome Data Viewer
Location:
13 B3; 13 35.55 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69760135..69783899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69612016..69635780)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34938 Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene Neighboring gene steroid 5 alpha-reductase 1 Neighboring gene STARR-seq mESC enhancer starr_34939 Neighboring gene importin 7 pseudogene Neighboring gene predicted gene, 52059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NSUN2 is critical for mouse oocyte meiosis and early embryonic development. Xu T, et al. Reproduction, 2024 Dec 1. PMID 39231094
  2. NSUN2 mediates distinct pathways to regulate enterovirus 71 replication. Liu L, et al. Virol Sin, 2024 Aug. PMID 38768712, Free PMC Article
  3. The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors. Frye M, et al. Curr Biol, 2006 May 23. PMID 16713953
  4. Cytosine-5 RNA methylation links protein synthesis to cell metabolism. Gkatza NA, et al. PLoS Biol, 2019 Jun. PMID 31199786, Free PMC Article
  5. RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57(Kip2) by an m(5)C-dependent manner. Mei L, et al. Cell Death Dis, 2020 Apr 24. PMID 32332707, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NSUN2 is critical for mouse oocyte meiosis and early embryonic development.
    Title: NSUN2 is critical for mouse oocyte meiosis and early embryonic development.
  2. NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.
    Title: NSUN2 mediates distinct pathways to regulate enterovirus 71 replication.
  3. NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.
    Title: NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.
  4. NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication.
    Title: NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication.
  5. Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1.
    Title: Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1.
  6. NSUN2-mediated M[5]c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
    Title: NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
  7. Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis.
    Title: Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis.
  8. RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
    Title: RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
  9. Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.
    Title: Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus.
  10. Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency.
    Title: Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Gene trapped (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA (cytidine-5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (cytidine-5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (cytidine-5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatoid body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA cytosine C(5)-methyltransferase NSUN2
Names
Myc-induced SUN domain containing protein
NOL1/NOP2/Sun domain family 2
mRNA cytosine C(5)-methyltransferase
myc-induced SUN domain-containing protein
tRNA (cytosine(34)-C(5))-methyltransferase
tRNA (cytosine-5-)-methyltransferase NSUN2
tRNA cytosine C(5)-methyltransferase
NP_663329.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145354.5 → NP_663329.3  RNA cytosine C(5)-methyltransferase NSUN2

    See identical proteins and their annotated locations for NP_663329.3

    Status: VALIDATED

    Source sequence(s)
    AI787627, AK030124, BX630130, CJ092700
    Consensus CDS
    CCDS36722.2
    UniProtKB/Swiss-Prot
    A0PJD6, Q1HFZ0, Q3U972, Q8BPG9, Q8CDF9, Q91YX9
    UniProtKB/TrEMBL
    A0A1S6GWH4
    Related
    ENSMUSP00000105321.5, ENSMUST00000109699.11
    Conserved Domains (1) summary
    COG0144
    Location:28 → 430
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    69760135..69783899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1HFZ0.2 GenPept UniProtKB/Swiss-Prot:Q1HFZ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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