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DSC2 desmocollin 2 [ Bos taurus (domestic cattle) ]

Gene ID: 281128, updated on 10-Oct-2024

Summary

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Official Symbol
DSC2provided by VGNC
Official Full Name
desmocollin 2provided by VGNC
Primary source
VGNC:VGNC:28213
See related
BGD:BT10086; Ensembl:ENSBTAG00000040584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See DSC2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (26027401..26065770)

Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904557 Neighboring gene desmocollin 1 Neighboring gene desmocollin 3 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complexity and expression patterns of the desmosomal cadherins. Koch PJ, et al. Proc Natl Acad Sci U S A, 1992 Jan 1. PMID 1729705, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in desmosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
desmocollin-2
Names
epithelial type 2 desmocollin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166526.1 → NP_001159998.1  desmocollin-2 precursor

    See identical proteins and their annotated locations for NP_001159998.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000024
    UniProtKB/TrEMBL
    F1MZF2
    Related
    ENSBTAP00000011306.6, ENSBTAT00000011306.7
    Conserved Domains (4) summary
    cd11304
    Location:247 → 351
    Cadherin_repeat; Cadherin tandem repeat domain
    smart01055
    Location:31 → 111
    Cadherin_pro; Cadherin prodomain like
    pfam00028
    Location:360 → 461
    Cadherin; Cadherin domain
    pfam01049
    Location:842 → 904
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26027401..26065770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005223953.5 → XP_005224010.1  desmocollin-2 isoform X1

    UniProtKB/TrEMBL
    F1MZF2
    Conserved Domains (4) summary
    cd11304
    Location:244 → 348
    Cadherin_repeat; Cadherin tandem repeat domain
    smart01055
    Location:31 → 111
    Cadherin_pro; Cadherin prodomain like
    pfam00028
    Location:357 → 458
    Cadherin; Cadherin domain
    pfam01049
    Location:839 → 901
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_005223955.5 → XP_005224012.1  desmocollin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M6K2, F1MZF2
    Related
    ENSBTAP00000066007.1, ENSBTAT00000084805.2
    Conserved Domains (3) summary
    cd11304
    Location:247 → 351
    Cadherin_repeat; Cadherin tandem repeat domain
    smart01055
    Location:31 → 111
    Cadherin_pro; Cadherin prodomain like
    pfam00028
    Location:360 → 461
    Cadherin; Cadherin domain

  3. XM_059880750.1 → XP_059736733.1  desmocollin-2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33545.1 GenPept UniProtKB/Swiss-Prot:P33545

Gene LinkOut

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