COX4I1 cytochrome c oxidase subunit 4I1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: COX4I1provided by VGNC
Official Full Name: cytochrome c oxidase subunit 4I1provided by VGNC
Primary source: VGNC:VGNC:27634
See related: Ensembl:ENSBTAG00000016079
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: COX4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (11758912..11767079)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of bovine cytochrome c oxidase crystallized at a neutral pH has been reported.
Title: Structure of bovine cytochrome c oxidase crystallized at a neutral pH using a fluorinated detergent.
Studies indicate that the patterns of charge translocation of cytochrome c oxidase coupled to transfer of the 3rd and 4th electrons are very similar.
Title: Cytochrome c oxidase: Intermediates of the catalytic cycle and their energy-coupled interconversion.
Studies indicate that time-resolved resonance Raman (RR) spectroscopy of whole mitochondria identified a band at 571cm(-1) arising from the oxygenated intermediate at Deltat=0.4, 0.6 and 1.4ms.
Title: Resonance Raman applications in investigations of cytochrome c oxidase.
Studies indicate that mutational amino acid replacement in proton channels, at the negative (N) side of membrane-inserted prokaryotic aa(3) oxidases, as well as Zn(2+) binding at this site in the bovine oxidase, uncouples proton pumping.
Title: Allosteric interactions and proton conducting pathways in proton pumping aa(3) oxidases: heme a as a key coupling element.
Studies indicate that X-ray structure of heart cytochrome c oxidase (CcO) suggest that O(2) molecules are transiently trapped at the Cu(B) site before binding to Fe(a3)(2+) to provide O(2)(-).
Title: Structural studies on bovine heart cytochrome c oxidase.
Studies indicate that nitric oxide (NO) binding to reduced ba(3) and bovine cytochrome aa3.
Title: Kinetic studies of the reactions of O(2) and NO with reduced Thermus thermophilus ba(3) and bovine aa(3) using photolabile carriers.
Studies indicate that photoexcitation of Ru (II) to Ru(II*) leads to rapid electron transfer to the ferric heme group in cytochrome c (Cc), followed by electron transfer to Cu(A) in cytochrome c oxidase (CcO) with a rate constant of 60,000s(-1).
Title: Design of photoactive ruthenium complexes to study electron transfer and proton pumping in cytochrome oxidase.
Studies suggest that the master-equation models address the question of how pumping can be achieved in a system in which all reaction steps are reversible.
Title: Proton-pumping mechanism of cytochrome c oxidase: a kinetic master-equation approach.
Studies suggest for the His291 model of proton pumping in cytochrome c oxidase (CcO).
Title: Coupled electron and proton transfer reactions during the O→E transition in bovine cytochrome c oxidase.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Names: COX IV-1; cytochrome c oxidase polypeptide IV; cytochrome c oxydase subunit 4

NP_001001439.1

EC 7.1.1.9

XP_005218495.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.