CLTA clathrin light chain A [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CLTAprovided by VGNC
Official Full Name: clathrin light chain Aprovided by VGNC
Primary source: VGNC:VGNC:27469
See related: BGD:BT20693; Ensembl:ENSBTAG00000001137
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CLTA2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	8	NC_037335.1 (60474071..60491845)

Chromosome 8 - NC_037335.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of clathrin coat with bound Hsc70 and auxilin.
Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
Binding of light chain increases the amount of detergent needed to induce detrimerization, suggesting light chains reinforced hub trimers.
Title: Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers.
Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly.
Title: Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_11485-11486:1000830840:1 (e-PCR)
- UniSTS:267201

AV026556 (e-PCR)
- UniSTS:165318

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables clathrin heavy chain binding	IEA Inferred from Electronic Annotation more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in clathrin-dependent endocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info	PubMed
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic endocytic zone cytoplasmic component	IEA Inferred from Electronic Annotation more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: clathrin light chain A

Names: clathrin, light chain (Lca); clathrin, light chain A2; clathrin, light polypeptide (Lca); lca

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.