U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDK5 cyclin dependent kinase 5 [ Bos taurus (domestic cattle) ]

Gene ID: 281066, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
CDK5provided by VGNC
Official Full Name
cyclin dependent kinase 5provided by VGNC
Primary source
VGNC:VGNC:27127
See related
BGD:BT23839; Ensembl:ENSBTAG00000007766
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CDK5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (113630206..113634537, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 8 Neighboring gene acid sensing ion channel subunit 3 Neighboring gene solute carrier family 4 member 2 Neighboring gene microRNA mir-6525 Neighboring gene Fas activated serine/threonine kinase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. Lew J, et al. J Biol Chem, 1992 Dec 25. PMID 1464604
  2. A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule. Kobayashi S, et al. FEBS Lett, 1993 Dec 6. PMID 8253190
  3. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Nikolic M, et al. Genes Dev, 1996 Apr 1. PMID 8846918
  4. Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. Lu Y, et al. J Biol Chem, 2011 Jun 10. PMID 21489990, Free PMC Article
  5. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. Li T, et al. J Biol Chem, 2007 Mar 2. PMID 17202132

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that PP1alpha is a downstream target of the NGF/Egr-1/Cdk5 pathway during NGF-induced differentiation of PC12 cells and suggest that PP1 phosphorylation promotes neuronal differentiation
    Title: Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC140720

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cyclin-dependent kinase 5
Names
PDPK
TPKII catalytic subunit
cell division protein kinase 5
cyclin-dependent-like kinase 5
proline-directed protein kinase 33 kDa subunit
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_776442.1
XP_059741373.1
XP_059741374.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174017.2 → NP_776442.1  cyclin-dependent kinase 5

    See identical proteins and their annotated locations for NP_776442.1

    Status: PROVISIONAL

    Source sequence(s)
    X82440
    UniProtKB/Swiss-Prot
    Q02399, Q0VCN5, Q6LBE2
    UniProtKB/TrEMBL
    A0AAF6YS17
    Related
    ENSBTAP00000088669.1, ENSBTAT00000098240.1
    Conserved Domains (1) summary
    cd07839
    Location:3 → 286
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    113630206..113634537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059885390.1 → XP_059741373.1  cyclin-dependent kinase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q02399, Q0VCN5, Q6LBE2
    Related
    ENSBTAP00000010212.6, ENSBTAT00000010212.7

  2. XM_059885391.1 → XP_059741374.1  cyclin-dependent kinase 5 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02399.2 GenPept UniProtKB/Swiss-Prot:Q02399

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.