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PLIN2 perilipin 2 [ Bos taurus (domestic cattle) ]

Gene ID: 280981, updated on 4-Oct-2024

Summary

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Official Symbol
PLIN2provided by VGNC
Official Full Name
perilipin 2provided by VGNC
Primary source
VGNC:VGNC:33030
See related
BGD:BT10600; Ensembl:ENSBTAG00000005718
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ADFP
Orthologs
human mouse all
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Genomic context

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See PLIN2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (25117164..25131174)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4C Neighboring gene ribosomal protein S6 Neighboring gene cytochrome c oxidase subunit 6B1-like Neighboring gene HAUS augmin like complex subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene Ras related GTP binding A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of different culture systems on adipocyte differentiation-related protein (ADRP) in bovine embryos. Al Darwich A, et al. Anim Reprod Sci, 2014 Mar. PMID 24560670
  2. ADFP promoter polymorphism associated with marbling score in Korean cattle. Cheong HS, et al. BMB Rep, 2009 Aug 31. PMID 19712591
  3. Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin. Nielsen RL, et al. J Dairy Sci, 1999 Dec. PMID 10629799
  4. Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis. Straub BK, et al. Hepatology, 2008 Jun. PMID 18393390
  5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate that bovine embryos at the blastocyst stage expressed ADRP mRNA and protein, and that the embryonic culture system modified this expression.
    Title: Effect of different culture systems on adipocyte differentiation-related protein (ADRP) in bovine embryos.
  2. 25 novel polymorphisms were identified within all exons and their flanking regions of ADFP, including the promoter region.
    Title: ADFP promoter polymorphism associated with marbling score in Korean cattle.
  3. Adipophilin and TIP47 are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.
    Title: Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC127212

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in lipid storage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of sequestering of triglyceride IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
perilipin-2
Names
ADRP
adipophilin
adipose differentiation-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173980.2 → NP_776405.1  perilipin-2

    See identical proteins and their annotated locations for NP_776405.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ011680
    UniProtKB/Swiss-Prot
    Q3T0Y0, Q9TUM6
    UniProtKB/TrEMBL
    A1L5C2
    Related
    ENSBTAP00000007519.3, ENSBTAT00000007519.5
    Conserved Domains (1) summary
    pfam03036
    Location:6 → 395
    Perilipin; Perilipin family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    25117164..25131174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005209905.4 → XP_005209962.1  perilipin-2 isoform X2

    UniProtKB/TrEMBL
    F1MHI1, Q8HZM7
    Related
    ENSBTAP00000031425.4, ENSBTAT00000031470.6
    Conserved Domains (1) summary
    pfam03036
    Location:7 → 395
    Perilipin; Perilipin family

  2. XM_024995432.2 → XP_024851200.1  perilipin-2 isoform X1

    UniProtKB/TrEMBL
    A1L5C2, F1N1N6
    Conserved Domains (1) summary
    pfam03036
    Location:7 → 395
    Perilipin; Perilipin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TUM6.1 GenPept UniProtKB/Swiss-Prot:Q9TUM6

Gene LinkOut

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