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TPPP tubulin polymerization promoting protein [ Bos taurus (domestic cattle) ]

Gene ID: 280968, updated on 4-Oct-2024

Summary

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Official Symbol
TPPPprovided by VGNC
Official Full Name
tubulin polymerization promoting proteinprovided by VGNC
Primary source
VGNC:VGNC:36258
See related
BGD:BT20541; Ensembl:ENSBTAG00000052247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
p25
Orthologs
human mouse all
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Genomic context

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See TPPP in Genome Data Viewer
Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (71467629..71488493)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 9 Neighboring gene probable palmitoyltransferase ZDHHC11B Neighboring gene uncharacterized LOC104975299 Neighboring gene uncharacterized LOC132343262 Neighboring gene centrosomal protein 72 Neighboring gene solute carrier family 9 member A3 Neighboring gene uncharacterized LOC132343263

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning of a novel brain-specific protein p25. Shiratsuchi A, et al. Biochim Biophys Acta, 1995 Aug 16. PMID 7647094
  2. A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions. Takahashi M, et al. FEBS Lett, 1991 Sep 2. PMID 1909972
  3. Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. Hlavanda E, et al. Biochemistry, 2002 Jul 9. PMID 12093283
  4. Dynamic subunit exchange and the regulation of microtubule assembly by the stress response protein human alphaB crystallin. Houck SA, et al. PLoS One, 2010 Jul 26. PMID 20668689, Free PMC Article
  5. TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. Tirián L, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14623963, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tubulin polymerization-promoting protein
Names
25 kDa brain-specific protein
brain-specific protein p25 alpha
p25-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173976.3 → NP_776401.1  tubulin polymerization-promoting protein

    See identical proteins and their annotated locations for NP_776401.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000020
    UniProtKB/Swiss-Prot
    A2VDP9, Q27957, Q9TRW3, Q9TRW4
    UniProtKB/TrEMBL
    A0AAF7AK28
    Conserved Domains (1) summary
    pfam05517
    Location:51 → 206
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    71467629..71488493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024981196.2 → XP_024836964.1  tubulin polymerization-promoting protein isoform X2

    UniProtKB/TrEMBL
    A0AAF7AK28
    Related
    ENSBTAP00000070614.2, ENSBTAT00000078768.2
    Conserved Domains (1) summary
    pfam05517
    Location:92 → 247
    p25-alpha

  2. XM_024981198.2 → XP_024836966.1  tubulin polymerization-promoting protein isoform X1

    UniProtKB/Swiss-Prot
    A2VDP9, Q27957, Q9TRW3, Q9TRW4
    UniProtKB/TrEMBL
    A0AAF7AK28
    Conserved Domains (1) summary
    pfam05517
    Location:51 → 206
    p25-alpha; p25-alpha

  3. XM_024981197.2 → XP_024836965.1  tubulin polymerization-promoting protein isoform X1

    UniProtKB/Swiss-Prot
    A2VDP9, Q27957, Q9TRW3, Q9TRW4
    UniProtKB/TrEMBL
    A0AAF7AK28
    Conserved Domains (1) summary
    pfam05517
    Location:51 → 206
    p25-alpha; p25-alpha

  4. XM_024981199.2 → XP_024836967.1  tubulin polymerization-promoting protein isoform X1

    UniProtKB/Swiss-Prot
    A2VDP9, Q27957, Q9TRW3, Q9TRW4
    UniProtKB/TrEMBL
    A0AAF7AK28
    Related
    ENSBTAP00000063795.2, ENSBTAT00000078973.2
    Conserved Domains (1) summary
    pfam05517
    Location:51 → 206
    p25-alpha; p25-alpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27957.1 GenPept UniProtKB/Swiss-Prot:Q27957

Gene LinkOut

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