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TEK TEK receptor tyrosine kinase [ Bos taurus (domestic cattle) ]

Gene ID: 280939, updated on 4-Oct-2024

Summary

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Official Symbol
TEKprovided by VGNC
Official Full Name
TEK receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:35735
See related
BGD:BT10817; Ensembl:ENSBTAG00000020148
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See TEK in Genome Data Viewer
Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (17050131..17153179, complement)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 3B Neighboring gene RNA exonuclease 1 homolog Neighboring gene equatorin Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19 Neighboring gene phospholipase A2 activating protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Tekari A, et al. Stem Cell Res Ther, 2016 May 23. PMID 27216150, Free PMC Article
  2. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Sato TN, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415706, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
    Title: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC139569

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiopoietin-1 receptor
Names
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
endothelial tyrosine kinase
tie-2/tek receptor tyrosine kinase
tyrosine kinase with Ig and EGF homology domains-2
tyrosine-protein kinase receptor TIE-2
NP_776389.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173964.2 → NP_776389.1  angiopoietin-1 receptor precursor

    See identical proteins and their annotated locations for NP_776389.1

    Status: PROVISIONAL

    Source sequence(s)
    X71424
    UniProtKB/Swiss-Prot
    Q06807
    UniProtKB/TrEMBL
    A0AAF6Z7V8
    Related
    ENSBTAP00000026836.6, ENSBTAT00000026836.7
    Conserved Domains (6) summary
    cd05088
    Location:817 → 1119
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00221
    Location:825 → 1093
    STYKc; Protein kinase; unclassified specificity
    cd00055
    Location:230 → 275
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:640 → 732
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:544 → 627
    fn3; Fibronectin type III domain
    pfam10430
    Location:24 → 118
    Ig_Tie2_1; Tie-2 Ig-like domain 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    17050131..17153179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06807.1 GenPept UniProtKB/Swiss-Prot:Q06807

Gene LinkOut

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