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PGF placental growth factor [ Bos taurus (domestic cattle) ]

Gene ID: 280894, updated on 4-Oct-2024

Summary

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Official Symbol
PGFprovided by VGNC
Official Full Name
placental growth factorprovided by VGNC
Primary source
VGNC:VGNC:32787
See related
Ensembl:ENSBTAG00000013688
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PlGF
Orthologs
human mouse all
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Genomic context

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See PGF in Genome Data Viewer
Location:
chromosome: 10
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (86200949..86214101, complement)

Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene ribosomal protein S6 kinase like 1 Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene mutL homolog 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The placental growth factor (PGF)--a positional and functional candidate gene influencing calving ease and stillbirth in German dairy cattle. Seidenspinner T, et al. Anim Genet, 2011 Feb. PMID 20477802
  2. Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2. Zhao B, et al. Microvasc Res, 2004 Nov. PMID 15501243
  3. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. Yonekura H, et al. J Biol Chem, 1999 Dec 3. PMID 10575000
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reports polymorphisms in the bovine PGF gene significantly associated with the maternal effect on stillbirth and calving ease in animals under selection.
    Title: The placental growth factor (PGF)--a positional and functional candidate gene influencing calving ease and stillbirth in German dairy cattle.
  2. placenta growth factor expression is regulated by both VEGF and hyperglycaemia via VEGFR-2
    Title: Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC137394

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vascular endothelial growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
placenta growth factor
Names
placental growth factor, vascular endothelial growth factor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173950.2 → NP_776375.1  placenta growth factor precursor

    See identical proteins and their annotated locations for NP_776375.1

    Status: PROVISIONAL

    Source sequence(s)
    AB004272
    UniProtKB/Swiss-Prot
    Q2KII8, Q9XS47
    UniProtKB/TrEMBL
    A0AAA9SM36
    Related
    ENSBTAP00000018196.4, ENSBTAT00000018196.6
    Conserved Domains (1) summary
    smart00141
    Location:50 → 132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    86200949..86214101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024997229.2 → XP_024852997.1  placenta growth factor isoform X2

    Conserved Domains (1) summary
    cl00116
    Location:50 → 108
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

  2. XM_005211921.4 → XP_005211978.1  placenta growth factor isoform X1

    See identical proteins and their annotated locations for XP_005211978.1

    UniProtKB/TrEMBL
    A0A3Q1MQB6
    Related
    ENSBTAP00000073796.1, ENSBTAT00000078686.2
    Conserved Domains (1) summary
    smart00141
    Location:50 → 132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XS47.1 GenPept UniProtKB/Swiss-Prot:Q9XS47

Gene LinkOut

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