LTA lymphotoxin alpha [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LTAprovided by VGNC
Official Full Name: lymphotoxin alphaprovided by VGNC
Primary source: VGNC:VGNC:31066
See related: BGD:BT10596; Ensembl:ENSBTAG00000000016
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (27720176..27725068, complement)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lymphotoxin-alpha

Names: LT-alpha; TNF superfamily, member 1; TNF-beta; tumor necrosis factor ligand superfamily member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013401.2 → NP_001013419.1 lymphotoxin-alpha precursor

See identical proteins and their annotated locations for NP_001013419.1

Status: PROVISIONAL

Source sequence(s)

BC114670

UniProtKB/Swiss-Prot

A4FUB6, Q06600

Related

ENSBTAP00000000018.3, ENSBTAT00000000018.4

Conserved Domains (1) summary

cd00184
Location:62 → 202

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

Range

27720176..27725068 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005223586.5 → XP_005223643.1 lymphotoxin-alpha isoform X1

See identical proteins and their annotated locations for XP_005223643.1

UniProtKB/Swiss-Prot

A4FUB6, Q06600

Conserved Domains (1) summary

cd00184
Location:62 → 202

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...