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LPL lipoprotein lipase [ Bos taurus (domestic cattle) ]

Gene ID: 280843, updated on 4-Oct-2024

Summary

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Official Symbol
LPLprovided by VGNC
Official Full Name
lipoprotein lipaseprovided by VGNC
Primary source
VGNC:VGNC:30969
See related
BGD:BT11268; Ensembl:ENSBTAG00000012855
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See LPL in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (66989665..67016694)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis-associated protein 31E1-like Neighboring gene uncharacterized LOC101903598 Neighboring gene thymosin beta-4-like Neighboring gene large ribosomal subunit protein uL30-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of bovine milk lipoprotein lipase. Yang CY, et al. J Biol Chem, 1989 Oct 5. PMID 2674142
  2. Molecular cloning and sequence of a cDNA coding for bovine lipoprotein lipase. Senda M, et al. Proc Natl Acad Sci U S A, 1987 Jul. PMID 2885834, Free PMC Article
  3. Lipoprotein lipases from cow, guinea-pig and man. Structural characterization and identification of protease-sensitive internal regions. Bengtsson-Olivecrona G, et al. Eur J Biochem, 1986 Dec 1. PMID 3536511
  4. Effect of glucose and insulin on lipoprotein lipase activity in adipose tissue and milk. Rao DR, et al. J Dairy Sci, 1973 Nov. PMID 4750859
  5. Endothelial cell heparanase modulation of lipoprotein lipase activity. Evidence that heparan sulfate oligosaccharide is an extracellular chaperone. Pillarisetti S, et al. J Biol Chem, 1997 Jun 20. PMID 9188470

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this report describes a novel mechanism of action for stimulation of LPL activity by apoC-II mimetic peptides.
    Title: Apolipoprotein C-II mimetic peptide is an efficient activator of lipoprotein lipase in human plasma as studied by a calorimetric approach.
  2. miR-224 regulated the adipogenic differentiation of bovine preadipocytes by targeting LPL.
    Title: MicroRNA-224 impairs adipogenic differentiation of bovine preadipocytes by targeting LPL.
  3. isothermal titration calorimetry (ITC) can be used for quantitative measurements of LPL activity and interactions under in vivo-like conditions, for comparisons of the properties of plasma samples from patients and control subjects as substrates for LPL, as well as for testing of drug candidates developed with the aim to affect the LPL system.
    Title: Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry.
  4. miR-29b targets LPL and TDG genes and regulates apoptosis and triglyceride production in mammary epithelial cells.
    Title: miR-29b Targets LPL and TDG Genes and Regulates Apoptosis and Triglyceride Production in MECs.
  5. apoC-I and apoC-III inhibit lipolysis by displacing LPL from lipid emulsion particles. We also propose a role for these apolipoproteins in the irreversible inactivation of LPL by factors such as angptl4.
    Title: Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets.
  6. ANGPTL4 is more accurately described as a reversible, noncompetitive inhibitor of LPL.
    Title: Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation.
  7. Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.
    Title: Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle.
  8. Single nucleotide polymorphisms of the LPL gene might be useful genetic markers for growth traits in the bovine reproduction and breeding.
    Title: Genetic polymorphisms of lipoprotein lipase gene and their associations with growth traits in Xiangxi cattle.
  9. Results describe the functional role of the secondary structure in the lipoprotein lipase-binding portion of apolipoprotein CII.
    Title: Site-directed mutagenesis of apolipoprotein CII to probe the role of its secondary structure for activation of lipoprotein lipase.
  10. regions that are responsive to activation by apoC-II
    Title: Identification of a lipoprotein lipase cofactor-binding site by chemical cross-linking and transfer of apolipoprotein C-II-responsive lipolysis from lipoprotein lipase to hepatic lipase.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC137861

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables apolipoprotein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipoprotein lipase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lipoprotein lipase
Names
phospholipase A1
NP_001068588.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075120.1 → NP_001068588.1  lipoprotein lipase precursor

    See identical proteins and their annotated locations for NP_001068588.1

    Status: PROVISIONAL

    Source sequence(s)
    BC118091
    UniProtKB/Swiss-Prot
    P11151, Q17R03
    Related
    ENSBTAP00000017086.5, ENSBTAT00000017086.6
    Conserved Domains (1) summary
    TIGR03230
    Location:36 → 476
    lipo_lipase; lipoprotein lipase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    66989665..67016694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11151.2 GenPept UniProtKB/Swiss-Prot:P11151

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.