LOX lysyl oxidase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: LOXprovided by VGNC
Official Full Name: lysyl oxidaseprovided by VGNC
Primary source: VGNC:VGNC:30951
See related: BGD:BT14850; Ensembl:ENSBTAG00000012994
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (31755215..31767581)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that proLOX could be processed by two different mechanisms producing two forms of active LOX.
Title: A novel proteolytic processing of prolysyl oxidase.
Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells
Title: Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells.
Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
Title: Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
In cases of vascular calcification, the decreased expression of LOX may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers.
Title: Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells.
Lysyl oxidase has a role in oxidizing basic fibroblast growth factor and inactivating its mitogenic potential
Title: Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential.

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General gene information

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Markers

MARC_64269-64270:1182200887:1 (e-PCR)
- UniSTS:508213

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein-lysine 6-oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-lysine oxidation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein-lysine 6-oxidase

NP_776357.2

EC 1.4.3.13

XP_005209160.1

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.