U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HK1 hexokinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 280817, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
HK1provided by VGNC
Official Full Name
hexokinase 1provided by VGNC
Primary source
VGNC:VGNC:29864
See related
Ensembl:ENSBTAG00000012380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HK1 in Genome Data Viewer
Location:
chromosome: 28
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (25655622..25768164)

Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene Suv3 like RNA helicase Neighboring gene hexokinase domain containing 1 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene tachykinin receptor 2 Neighboring gene tetraspanin 15 Neighboring gene small ribosomal subunit protein uS2B-like

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bovine hexokinase type I: full-length cDNA sequence and characterisation of the recombinant enzyme. Andreoni F, et al. Mol Cell Biochem, 2005 Jan. PMID 15724432
  2. Synthesis and characterization of a bovine hexokinase 1 cDNA probe by mixed oligonucleotide primed amplification of cDNA using high complexity primer mixtures. Griffin LD, et al. Biochem Med Metab Biol, 1989 Apr. PMID 2719857
  3. Mammalian hexokinase 1: evolutionary conservation and structure to function analysis. Griffin LD, et al. Genomics, 1991 Dec. PMID 1783373
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fructokinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glucokinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mannokinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
hexokinase-1
Names
HK I
brain form hexokinase
hexokinase I
hexokinase type I
NP_001012686.1
XP_024842269.1
XP_059738389.1
XP_059738390.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012668.2 → NP_001012686.1  hexokinase-1

    See identical proteins and their annotated locations for NP_001012686.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000028
    UniProtKB/TrEMBL
    A0AAA9S4V8, F1MIQ6, Q5W5U3
    Related
    ENSBTAP00000063116.1, ENSBTAT00000078825.2
    Conserved Domains (3) summary
    PTZ00107
    Location:12 → 460
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:469 → 667
    Hexokinase_1; Hexokinase
    pfam03727
    Location:673 → 907
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    25655622..25768164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986501.2 → XP_024842269.1  hexokinase-1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9S4V8, A0AAA9T0D2
    Conserved Domains (3) summary
    pfam00349
    Location:473 → 671
    Hexokinase_1
    pfam03727
    Location:677 → 911
    Hexokinase_2
    cl27242
    Location:26 → 464
    Hexokinase_2

  2. XM_059882407.1 → XP_059738390.1  hexokinase-1 isoform X2

  3. XM_059882406.1 → XP_059738389.1  hexokinase-1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T0D2
    Related
    ENSBTAP00000091153.1, ENSBTAT00000131462.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27595.1 GenPept UniProtKB/Swiss-Prot:P27595

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials