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Desi1 desumoylating isopeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 28075, updated on 2-Nov-2024

Summary

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Official Symbol
Desi1provided by MGI
Official Full Name
desumoylating isopeptidase 1provided by MGI
Primary source
MGI:MGI:106313
See related
Ensembl:ENSMUSG00000022472 AllianceGenome:MGI:106313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DeSI-1; Pppde2; Fam152b; D15Wsu75e
Summary
Enables deSUMOylase activity and identical protein binding activity. Involved in protein desumoylation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in extraembryonic component. Orthologous to human DESI1 (desumoylating isopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 105.5), thymus adult (RPKM 62.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Desi1 in Genome Data Viewer
Location:
15 E1; 15 38.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81876724..81900364, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81992523..82016258, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 6 Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene RIKEN cDNA 4930407I10 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DeSUMOylating isopeptidase: a second class of SUMO protease. Shin EJ, et al. EMBO Rep, 2012 Apr. PMID 22370726, Free PMC Article
  2. Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Kaput J, et al. Physiol Genomics, 2004 Aug 11. PMID 15306695
  3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A new deSUMOylase named DeSI-1 (DeSumoylating Isopeptidase 1), was identified.
    Title: DeSUMOylating isopeptidase: a second class of SUMO protease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deSUMOylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables importin-alpha family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in macromolecule depalmitoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
desumoylating isopeptidase 1
Names
PPPDE peptidase domain containing 2
PPPDE peptidase domain-containing protein 2
S-depalmitoylase DESI1
family with sequence similarity 152, member B
palmitoyl protein thioesterase DESI1
NP_001343470.1
NP_598856.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356541.2 → NP_001343470.1  desumoylating isopeptidase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102176
    Conserved Domains (1) summary
    pfam05903
    Location:7 → 148
    Peptidase_C97; PPPDE putative peptidase domain

  2. NM_134095.4 → NP_598856.1  desumoylating isopeptidase 1 isoform 1

    See identical proteins and their annotated locations for NP_598856.1

    Status: VALIDATED

    Source sequence(s)
    AC102176
    Consensus CDS
    CCDS27681.1
    UniProtKB/Swiss-Prot
    Q3V2M9, Q9CQT7
    Related
    ENSMUSP00000121504.2, ENSMUST00000152227.8
    Conserved Domains (1) summary
    pfam05903
    Location:7 → 149
    Peptidase_C97; PPPDE putative peptidase domain

RNA

  1. NR_177966.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102176
    Related
    ENSMUST00000146628.8

  2. NR_177967.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102176

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81876724..81900364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQT7.1 GenPept UniProtKB/Swiss-Prot:Q9CQT7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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