CA2 carbonic anhydrase 2 [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: CA2
Gene description: carbonic anhydrase 2
See related: BGD:BT11203; Ensembl:ENSBTAG00000017733
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	14	NC_037341.1 (76994568..77012210, complement)

Chromosome 14 - NC_037341.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of cross-beta-structure as a key determinant of carbonic anhydrase amyloid fibrils cytotoxicity.
Title: The presence of cross-β-structure as a key determinant of carbonic anhydrase amyloid fibrils cytotoxicity.
A single substitution of the amino acid in three mutant forms of CA II affected the native state of the protein but did not change its unfolding pathway. On the contrary, the inserted disulfide bridge in three other mutant forms of CA II affected the protein unfolding pathway.
Title: Experimental approach to study the effect of mutations on the protein folding pathway.
This study provides the first evidence that extra-platelet nitrite and erythrocytic CAII may modulate platelet function in a cGMP-dependent manner.
Title: Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets.
binding of dorzolamide to bovine and human carbonic anhydrase II
Title: Spectroscopic and molecular modeling studies on binding of dorzolamide to bovine and human carbonic anhydrase II.
Increasing the number and distribution of surface acidic groups of CAII is sufficient to function in high-salt environments.
Title: Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst.
Folding analysis of the zinc protein, carbonic anhydrase 2 was performed using electrospray ionization ion mobility spectrometry coupled with collision-induced dissociation.
Title: Ion mobility and collision-induced dissociation analysis of carbonic anhydrase 2.
Intense positive staining for CA-II was found in luminal duct cells and for the first time also inside the duct lumen, clearly demonstrating the expression and secretion of salivary CA-II in bovine parotid glands.
Title: Carbonic anhydrase II is secreted from bovine parotid glands.
Carbonic anhydrase II (BCA II) when incubated in mildly denaturing conditions showed that the partially unfolded conformers assemble together and form ordered amyloid aggregates.
Title: Formation of amyloid fibrils by bovine carbonic anhydrase.
The urea-induced unfolding of bovine carbonic anhydrase II, BCA II, is characterized by a combination of high-resolution NMR, circular dichroism spectroscopy and small angle X-ray scattering.
Title: Dynamics of oligomer formation by denatured carbonic anhydrase II.
kinetics of refolding of carbonic anhydrase II following transfer from a buffer containing 5 m guanidinium chloride to a buffer containing 0.5 m guanidinium chloride
Title: Effect of high concentration of inert cosolutes on the refolding of an enzyme: carbonic anhydrase B in sucrose and ficoll 70.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: carbonic anhydrase 2

Names: CA-II; carbonate dehydratase II; carbonic anhydrase II; cyanamide hydratase CA2

NP_848667.1

EC 4.2.1.1

EC 4.2.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178572.2 → NP_848667.1 carbonic anhydrase 2

See identical proteins and their annotated locations for NP_848667.1

Status: PROVISIONAL

Source sequence(s)

AY240020

UniProtKB/Swiss-Prot

P00921, Q3ZBJ5, Q865Y7

UniProtKB/TrEMBL

F1N0H3

Related

ENSBTAP00000023581.4, ENSBTAT00000023581.5

Conserved Domains (1) summary

cl00012
Location:1 → 256

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...