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ADM adrenomedullin [ Bos taurus (domestic cattle) ]

Gene ID: 280713, updated on 4-Oct-2024

Summary

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Official Symbol
ADMprovided by VGNC
Official Full Name
adrenomedullinprovided by VGNC
Primary source
VGNC:VGNC:25681
See related
BGD:BT10911; Ensembl:ENSBTAG00000021048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ADM in Genome Data Viewer
Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (42377559..42379867, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 141 Neighboring gene uncharacterized LOC101906823 Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene microRNA mir-6518 Neighboring gene SET binding factor 2 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC104974249

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adrenomedullin regulates the speed of oviductal fluid flow in cattle. Yoshimoto Y, et al. Mol Reprod Dev, 2017 Aug. PMID 28621496
  2. Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla. Kitamura K, et al. Peptides, 2001 Nov. PMID 11754956
  3. Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporine. Barker S, et al. Life Sci, 1998. PMID 9585168
  4. Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells. Takahashi K, et al. Hypertens Res, 2006 Jun. PMID 16940707
  5. Temporo-spatial expression of adrenomedullin and its receptors in the bovine placenta. Hayashi KG, et al. Reprod Biol Endocrinol, 2013 Jul 13. PMID 23849271, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studied adrenomedullin's (ADM) role in oviductal fluid flow in cattle.
    Title: Adrenomedullin regulates the speed of oviductal fluid flow in cattle.
  2. Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells.
    Title: Temporo-spatial expression of adrenomedullin and its receptors in the bovine placenta.
  3. The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells.
    Title: Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables adrenomedullin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adrenomedullin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pro-adrenomedullin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173888.3 → NP_776313.1  pro-adrenomedullin precursor

    See identical proteins and their annotated locations for NP_776313.1

    Status: PROVISIONAL

    Source sequence(s)
    BC123826
    UniProtKB/Swiss-Prot
    O62827, Q08DC5, Q95KP0
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 151
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42377559..42379867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024974972.2 → XP_024830740.1  pro-adrenomedullin isoform X2

    UniProtKB/TrEMBL
    A0AAF6Z8H7
    Related
    ENSBTAP00000028036.5, ENSBTAT00000028036.6
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 150
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  2. XM_005215893.5 → XP_005215950.1  pro-adrenomedullin isoform X1

    See identical proteins and their annotated locations for XP_005215950.1

    UniProtKB/Swiss-Prot
    O62827, Q08DC5, Q95KP0
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 151
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62827.2 GenPept UniProtKB/Swiss-Prot:O62827

Gene LinkOut

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