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Afm afamin [ Mus musculus (house mouse) ]

Gene ID: 280662, updated on 2-Nov-2024

Summary

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Official Symbol
Afmprovided by MGI
Official Full Name
afaminprovided by MGI
Primary source
MGI:MGI:2429409
See related
Ensembl:ENSMUSG00000029369 AllianceGenome:MGI:2429409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alf; alpha-Alb
Summary
Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; liver; and metanephros. Orthologous to human AFM (afamin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 42.9), liver E18 (RPKM 22.8) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Afm in Genome Data Viewer
Location:
5 E1; 5 44.78 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90666808..90701403)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90518949..90553544)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene albumin (Alb) 5' regulatory region Neighboring gene albumin Neighboring gene alpha fetoprotein (Afp) 5' regulatory region Neighboring gene alpha fetoprotein Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene albumin superfamily member 1 Neighboring gene predicted gene, 42109

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway. Kim BJ, et al. Bone, 2012 Sep. PMID 22749887
  2. The mouse alpha-albumin (afamin) promoter is differentially regulated by hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β. Liu H, et al. DNA Cell Biol, 2011 Mar. PMID 20979532, Free PMC Article
  3. Alpha-fetoprotein related gene (ARG): a new member of the albumin gene family that is no longer functional in primates. Naidu S, et al. Gene, 2010 Jan 1. PMID 19733224, Free PMC Article
  4. Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Gabant P, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12297623, Free PMC Article
  5. Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. Bernhard OK, et al. J Proteome Res, 2007 Mar. PMID 17330941

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Afamin is one of osteoclast-derived chemokines that affect preosteoblasts through the activation of the Akt-signaling pathway.
    Title: Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway.
  2. Data indicate that HNF1alpha is a more potent activator of AFM promoter than is HNF1beta.
    Title: The mouse alpha-albumin (afamin) promoter is differentially regulated by hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4) 

General gene information

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Markers

Homology

Clone Names

  • MGC118711

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables vitamin E binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vitamin E binding ISO
Inferred from Sequence Orthology
more info
  
enables vitamin E binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport within extracellular region ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport within extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vitamin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
afamin
Names
alpha-albumin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145146.3 → NP_660128.2  afamin precursor

    See identical proteins and their annotated locations for NP_660128.2

    Status: VALIDATED

    Source sequence(s)
    AC135240, AC140220
    Consensus CDS
    CCDS39141.1
    UniProtKB/Swiss-Prot
    O89020, Q3UNV0, Q497E6, Q8R0J9
    Related
    ENSMUSP00000108804.3, ENSMUST00000113179.9
    Conserved Domains (2) summary
    cd00015
    Location:413 → 596
    ALBUMIN; Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...
    pfam00273
    Location:33 → 202
    Serum_albumin; Serum albumin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90666808..90701403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89020.2 GenPept UniProtKB/Swiss-Prot:O89020

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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