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GOLGB1 golgin B1 [ Homo sapiens (human) ]

Gene ID: 2804, updated on 7-Apr-2024

Summary

Official Symbol
GOLGB1provided by HGNC
Official Full Name
golgin B1provided by HGNC
Primary source
HGNC:HGNC:4429
See related
Ensembl:ENSG00000173230 MIM:602500; AllianceGenome:HGNC:4429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCP; GCP372; GOLIM1
Summary
Enables RNA binding activity. Involved in protein localization to pericentriolar material. Located in Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 16.1), prostate (RPKM 15.7) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See GOLGB1 in Genome Data Viewer
Location:
3q13.33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (121663201..121749966, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (124383093..124471671, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121382048..121468588, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hematopoietic cell-specific Lyn substrate 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20346 Neighboring gene RNA, 7SL, cytoplasmic 172, pseudogene Neighboring gene RNA, U4 small nuclear 62, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:121449808-121451007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20348 Neighboring gene IQ motif containing B1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20349 Neighboring gene ELL associated factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with the Golgi apparatus protein giantin in HIV-transfected 293T cells PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 co-localizes with the Golgi apparatus protein giantin in HIV-transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ37232, DKFZp686F09142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to pericentriolar material IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in Golgi stack TAS
Traceable Author Statement
more info
PubMed 
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
golgin subfamily B member 1
Names
372 kDa Golgi complex-associated protein
giantin
golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1
golgi integral membrane protein 1
golgin B1, golgi integral membrane protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256486.2NP_001243415.1  golgin subfamily B member 1 isoform 1

    See identical proteins and their annotated locations for NP_001243415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA127633, AB371588, AB593126, BP320001
    Consensus CDS
    CCDS58847.1
    UniProtKB/TrEMBL
    C9J8Q0
    Related
    ENSP00000377275.3, ENST00000393667.8
    Conserved Domains (4) summary
    COG1196
    Location:8141650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19042778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13942326
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11601223
    Ax_dynein_light; Axonemal dynein light chain
  2. NM_001256487.2NP_001243416.1  golgin subfamily B member 1 isoform 3

    See identical proteins and their annotated locations for NP_001243416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA127633, AB593126, BP320001, D25542
    UniProtKB/TrEMBL
    C9J8Q0
    Conserved Domains (4) summary
    COG1196
    Location:7751611
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18652739
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13552287
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11211184
    Ax_dynein_light; Axonemal dynein light chain
  3. NM_001256488.2NP_001243417.1  golgin subfamily B member 1 isoform 4

    See identical proteins and their annotated locations for NP_001243417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at its 5' end and initiates translation at a downstream start codon, compared to variant 1. It also lacks an internal in-frame exon and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AA127633, AB593126, X75304
    UniProtKB/TrEMBL
    A0A8Q3WKA7
    Conserved Domains (4) summary
    COG1196
    Location:7341570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18242698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13142246
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:10801143
    Ax_dynein_light; Axonemal dynein light chain
  4. NM_001366282.2NP_001353211.1  golgin subfamily B member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    Consensus CDS
    CCDS93348.1
    UniProtKB/TrEMBL
    A0A8J9C4H3, C9J8Q0
    Related
    ENSP00000484083.2, ENST00000614479.5
    Conserved Domains (1) summary
    cl25732
    Location:13172187
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001366283.2NP_001353212.1  golgin subfamily B member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    Consensus CDS
    CCDS93347.1
    UniProtKB/TrEMBL
    A0A8Q3WKA7, E7EU81
    Related
    ENSP00000418231.2, ENST00000494517.6
    Conserved Domains (1) summary
    cl25732
    Location:12762146
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001366284.2NP_001353213.1  golgin subfamily B member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    UniProtKB/TrEMBL
    A0A8Q3WKA7
    Conserved Domains (1) summary
    cl25732
    Location:12372107
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001389631.1NP_001376560.1  golgin subfamily B member 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC119736, AC133750
    UniProtKB/TrEMBL
    A0A8Q3SHH2
    Conserved Domains (2) summary
    COG1196
    Location:12722142
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:151979
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  8. NM_004487.5NP_004478.3  golgin subfamily B member 1 isoform 2

    See identical proteins and their annotated locations for NP_004478.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 5' and 3' coding regions, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA127633, AB593126, X75304
    Consensus CDS
    CCDS3004.1
    UniProtKB/Swiss-Prot
    B2ZZ91, D3DN92, E7EP74, F1T0J2, Q14398, Q14789
    UniProtKB/TrEMBL
    C9J8Q0
    Related
    ENSP00000341848.5, ENST00000340645.10
    Conserved Domains (4) summary
    COG1196
    Location:8091645
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18992773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13892321
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11551218
    Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    121663201..121749966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447994.1XP_047303950.1  golgin subfamily B member 1 isoform X8

  2. XM_047447992.1XP_047303948.1  golgin subfamily B member 1 isoform X7

  3. XM_047447989.1XP_047303945.1  golgin subfamily B member 1 isoform X4

  4. XM_047447988.1XP_047303944.1  golgin subfamily B member 1 isoform X2

  5. XM_011512699.4XP_011511001.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_011511001.1

    UniProtKB/TrEMBL
    C9J8Q0
    Conserved Domains (4) summary
    COG1196
    Location:8141650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19042778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13942326
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11601223
    Ax_dynein_light; Axonemal dynein light chain
  6. XM_047447995.1XP_047303951.1  golgin subfamily B member 1 isoform X9

    Related
    ENSP00000417767.2, ENST00000489400.2
  7. XM_006713591.3XP_006713654.1  golgin subfamily B member 1 isoform X8

    UniProtKB/TrEMBL
    H0Y867
    Conserved Domains (4) summary
    COG1196
    Location:7341570
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18242698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13142246
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:10801143
    Ax_dynein_light; Axonemal dynein light chain
  8. XM_005247373.3XP_005247430.1  golgin subfamily B member 1 isoform X7

    UniProtKB/TrEMBL
    A0A8Q3WKA7
    Conserved Domains (4) summary
    COG1196
    Location:7731609
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18632737
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13532285
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11191182
    Ax_dynein_light; Axonemal dynein light chain
  9. XM_047447990.1XP_047303946.1  golgin subfamily B member 1 isoform X5

    Related
    ENSP00000511618.1, ENST00000694958.1
  10. XM_006713589.3XP_006713652.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    A0A8Q3SHH2
    Conserved Domains (4) summary
    COG1196
    Location:8081644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18982772
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13882320
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11541217
    Ax_dynein_light; Axonemal dynein light chain
  11. XM_006713588.3XP_006713651.1  golgin subfamily B member 1 isoform X2

    UniProtKB/TrEMBL
    C9J8Q0
    Conserved Domains (4) summary
    COG1196
    Location:8091645
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18992773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13892321
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11551218
    Ax_dynein_light; Axonemal dynein light chain
  12. XM_047447993.1XP_047303949.1  golgin subfamily B member 1 isoform X8

  13. XM_017006191.2XP_016861680.1  golgin subfamily B member 1 isoform X7

    UniProtKB/TrEMBL
    A0A8Q3WKA7
    Related
    ENSP00000511640.1, ENST00000695008.1
    Conserved Domains (4) summary
    COG1196
    Location:7731609
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18632737
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13532285
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11191182
    Ax_dynein_light; Axonemal dynein light chain
  14. XM_017006190.2XP_016861679.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    A0A8Q3SHH2
    Related
    ENSP00000511648.1, ENST00000695017.1
    Conserved Domains (4) summary
    COG1196
    Location:8081644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18982772
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13882320
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11541217
    Ax_dynein_light; Axonemal dynein light chain
  15. XM_017006189.2XP_016861678.1  golgin subfamily B member 1 isoform X2

    UniProtKB/TrEMBL
    C9J8Q0
    Conserved Domains (4) summary
    COG1196
    Location:8091645
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:18992773
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13892321
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11551218
    Ax_dynein_light; Axonemal dynein light chain
  16. XM_047447987.1XP_047303943.1  golgin subfamily B member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8J9C4H3
  17. XM_005247371.5XP_005247428.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_005247428.1

    UniProtKB/TrEMBL
    C9J8Q0
    Conserved Domains (4) summary
    COG1196
    Location:8141650
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:19042778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01576
    Location:13942326
    Myosin_tail_1; Myosin tail
    pfam10211
    Location:11601223
    Ax_dynein_light; Axonemal dynein light chain
  18. XM_047447991.1XP_047303947.1  golgin subfamily B member 1 isoform X6

  19. XM_017006195.2XP_016861684.1  golgin subfamily B member 1 isoform X10

    UniProtKB/TrEMBL
    A0A8Q3SHP0
    Related
    ENSP00000511621.1, ENST00000694973.1
  20. XM_047447996.1XP_047303952.1  golgin subfamily B member 1 isoform X11

    Related
    ENSP00000511622.1, ENST00000694974.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    124383093..124471671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346237.1XP_054202212.1  golgin subfamily B member 1 isoform X8

  2. XM_054346234.1XP_054202209.1  golgin subfamily B member 1 isoform X7

  3. XM_054346229.1XP_054202204.1  golgin subfamily B member 1 isoform X4

  4. XM_054346226.1XP_054202201.1  golgin subfamily B member 1 isoform X2

  5. XM_054346222.1XP_054202197.1  golgin subfamily B member 1 isoform X1

  6. XM_054346224.1XP_054202199.1  golgin subfamily B member 1 isoform X3

  7. XM_054346221.1XP_054202196.1  golgin subfamily B member 1 isoform X1

  8. XM_054346236.1XP_054202211.1  golgin subfamily B member 1 isoform X8

  9. XM_054346233.1XP_054202208.1  golgin subfamily B member 1 isoform X7

  10. XM_054346228.1XP_054202203.1  golgin subfamily B member 1 isoform X4

  11. XM_054346225.1XP_054202200.1  golgin subfamily B member 1 isoform X2

  12. XM_054346238.1XP_054202213.1  golgin subfamily B member 1 isoform X9

  13. XM_054346235.1XP_054202210.1  golgin subfamily B member 1 isoform X8

  14. XM_054346232.1XP_054202207.1  golgin subfamily B member 1 isoform X7

  15. XM_054346230.1XP_054202205.1  golgin subfamily B member 1 isoform X5

  16. XM_054346227.1XP_054202202.1  golgin subfamily B member 1 isoform X4

  17. XM_054346223.1XP_054202198.1  golgin subfamily B member 1 isoform X2

  18. XM_054346231.1XP_054202206.1  golgin subfamily B member 1 isoform X6

  19. XM_054346239.1XP_054202214.1  golgin subfamily B member 1 isoform X10

  20. XM_054346240.1XP_054202215.1  golgin subfamily B member 1 isoform X11