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Kctd19 potassium channel tetramerisation domain containing 19 [ Mus musculus (house mouse) ]

Gene ID: 279499, updated on 2-Nov-2024

Summary

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Official Symbol
Kctd19provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 19provided by MGI
Primary source
MGI:MGI:3045294
See related
Ensembl:ENSMUSG00000051648 AllianceGenome:MGI:3045294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4922504H04Rik
Summary
Involved in male meiotic nuclear division. Located in nucleus. Is expressed in primary spermatocyte; secondary spermatocyte; seminiferous tubule; spermatid; and testis. Orthologous to human KCTD19 (potassium channel tetramerization domain containing 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 76.8) See more
Orthologs
human all
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Genomic context

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See Kctd19 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106109433..106140134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105382801..105413502, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene formin homology 2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene leucine rich repeat containing 36 Neighboring gene tubulin polymerization-promoting protein family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression. Zhou X, et al. Cell Prolif, 2024 Apr. PMID 37921559, Free PMC Article
  2. Homozygous nonsense variants of KCTD19 cause male infertility in humans and mice. Zhang Y, et al. J Genet Genomics, 2023 Aug. PMID 37257643
  3. Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia. Wang W, et al. Hum Reprod, 2023 Jul 5. PMID 37192818
  4. The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. Li Y, et al. J Genet Genomics, 2022 Nov. PMID 35341968
  5. Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity. Kuribayashi S, et al. Reprod Med Biol, 2023 Jan-Dec. PMID 36845001, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression.
    Title: ZFP541 and KCTD19 regulate chromatin organization and transcription programs for male meiotic progression.
  2. Homozygous nonsense variants of KCTD19 cause male infertility in humans and mice.
    Title: Homozygous nonsense variants of KCTD19 cause male infertility in humans and mice.
  3. Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia.
    Title: Biallelic variants in KCTD19 associated with male factor infertility and oligoasthenoteratozoospermia.
  4. KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
    Title: KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
  5. Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
    Title: Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107186

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301173.1 → NP_001288102.1  BTB/POZ domain-containing protein KCTD19 isoform 2

    See identical proteins and their annotated locations for NP_001288102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC124584, BC092530
    Consensus CDS
    CCDS80922.1
    UniProtKB/Swiss-Prot
    Q562E2, Q8C628
    Related
    ENSMUSP00000130831.2, ENSMUST00000167294.8
    Conserved Domains (1) summary
    cl02518
    Location:18 → 72
    BTB; BTB/POZ domain

  2. NM_177791.3 → NP_808459.1  BTB/POZ domain-containing protein KCTD19 isoform 1

    See identical proteins and their annotated locations for NP_808459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC092530, BC125431
    Consensus CDS
    CCDS40459.1
    UniProtKB/Swiss-Prot
    Q562E2
    Related
    ENSMUSP00000050687.7, ENSMUST00000063071.13
    Conserved Domains (3) summary
    cd18373
    Location:15 → 112
    BTB1_POZ_KCTD19; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19)
    cd18374
    Location:420 → 518
    BTB2_POZ_KCTD19; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19)
    cl38908
    Location:179 → 256
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106109433..106140134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248400.3 → XP_011246702.1  BTB/POZ domain-containing protein KCTD19 isoform X2

    Conserved Domains (3) summary
    cd18373
    Location:27 → 124
    BTB1_POZ_KCTD19; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19)
    cd18374
    Location:409 → 507
    BTB2_POZ_KCTD19; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19)
    cl38908
    Location:196 → 268
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_011248399.3 → XP_011246701.1  BTB/POZ domain-containing protein KCTD19 isoform X1

    Conserved Domains (3) summary
    cd18373
    Location:27 → 124
    BTB1_POZ_KCTD19; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19)
    cd18374
    Location:432 → 530
    BTB2_POZ_KCTD19; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19)
    cl38908
    Location:196 → 268
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q562E2.2 GenPept UniProtKB/Swiss-Prot:Q562E2

Gene LinkOut

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