Trpa1 transient receptor potential cation channel, subfamily A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpa1provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily A, member 1provided by MGI
Primary source: MGI:MGI:3522699
See related: Ensembl:ENSMUSG00000032769 AllianceGenome:MGI:3522699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anktm1; TRPA1b
Summary: Enables calcium channel activity. Involved in cell surface receptor signaling pathway; detection of mechanical stimulus involved in sensory perception; and response to organic cyclic compound. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception of pain; response to hydrogen peroxide; and thermoception. Located in stereocilium bundle. Is expressed in cochlea; dorsal root ganglion; glossopharyngeal ganglion; and lumbar dorsal root ganglion. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 4.5 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (14942868..14989086, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (14872644..14918862, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation.
Title: TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation.
TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1.
Title: TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1.
Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents.
Title: Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents.
Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization.
Title: Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization.
Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.
Title: Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Title: Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
The Lack of TRPA1 Ion Channel Does Not Affect the Chronic Stress-Induced Activation of the Locus Ceruleus.
Title: The Lack of TRPA1 Ion Channel Does Not Affect the Chronic Stress-Induced Activation of the Locus Ceruleus.
Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission.
Title: Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission.
A Novel Flp Reporter Mouse Shows That TRPA1 Expression Is Largely Limited to Sensory Neuron Subsets.
Title: A Novel Flp Reporter Mouse Shows That TRPA1 Expression Is Largely Limited to Sensory Neuron Subsets.
Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation.
Title: Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation.

Submit: New GeneRIF Correction See all GeneRIFs (275)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (8) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpa1 (e-PCR), detects polymorphism
- UniSTS:531237

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables osmolarity-sensing monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables temperature-gated cation channel activity	ISO Inferred from Sequence Orthology more info
enables temperature-gated cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to carbon dioxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cold	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood circulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cold	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thermoception	IDA Inferred from Direct Assay more info	PubMed
involved_in urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium bundle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel subfamily A member 1

Names: ankyrin-like with transmembrane domains protein 1; wasabi receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348288.1 → NP_001335217.1 transient receptor potential cation channel subfamily A member 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

AC121789, AK045771, KF460461

Consensus CDS

CCDS87814.1

UniProtKB/TrEMBL

V5TCP9

Related

ENSMUSP00000157371.2, ENSMUST00000235071.2

Conserved Domains (4) summary

cd00204
Location:93 → 219

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:98 → 129

ANK; ANK repeat [structural motif]

pfam00520
Location:768 → 945

Ion_trans; Ion transport protein

pfam12796
Location:41 → 129

Ank_2; Ankyrin repeats (3 copies)
NM_177781.5 → NP_808449.1 transient receptor potential cation channel subfamily A member 1 isoform 1

See identical proteins and their annotated locations for NP_808449.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC121789, AK045771

Consensus CDS

CCDS35516.1

UniProtKB/Swiss-Prot

Q0VBN5, Q8BLA8

Related

ENSMUSP00000043594.5, ENSMUST00000041447.5

Conserved Domains (4) summary

sd00045
Location:98 → 129

ANK; ANK repeat [structural motif]

pfam00520
Location:799 → 975

Ion_trans; Ion transport protein

pfam12796
Location:487 → 578

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:101 → 373

Ank_2; Ankyrin repeats (3 copies)