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Tm4sf19 transmembrane 4 L six family member 19 [ Mus musculus (house mouse) ]

Gene ID: 277203, updated on 2-Nov-2024

Summary

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Official Symbol
Tm4sf19provided by MGI
Official Full Name
transmembrane 4 L six family member 19provided by MGI
Primary source
MGI:MGI:3645933
See related
Ensembl:ENSMUSG00000079625 AllianceGenome:MGI:3645933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG277203
Summary
Predicted to be active in membrane. Is expressed in pancreas. Orthologous to human TM4SF19 (transmembrane 4 L six family member 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 1.2), spleen adult (RPKM 0.2) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Tm4sf19 in Genome Data Viewer
Location:
16 B3; 16 22.66 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32218823..32227397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32400012..32409234)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:32332099-32332400 Neighboring gene predicted gene 8387 Neighboring gene UBX domain protein 7 Neighboring gene predicted gene, 20056 Neighboring gene STARR-positive B cell enhancer ABC_E8997 Neighboring gene predicted gene, 53948 Neighboring gene dynein light chain Tctex-type 2B Neighboring gene STARR-positive B cell enhancer mm9_chr16:32430841-32431142 Neighboring gene STARR-positive B cell enhancer ABC_E9428 Neighboring gene phosphate cytidylyltransferase 1, choline, alpha isoform

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction. Choi C, et al. Nat Commun, 2024 Mar 30. PMID 38555350, Free PMC Article
  2. Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss. Park S, et al. Metabolism, 2024 Feb. PMID 38016540
  3. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, et al. Mol Psychiatry, 2021 Mar. PMID 30976085, Free PMC Article
  4. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Anderson KR, et al. Development, 2011 Aug. PMID 21750032, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction.
    Title: TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction.
  2. Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
    Title: Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane 4 L6 family member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160402.1 → NP_001153874.1  transmembrane 4 L6 family member 19

    See identical proteins and their annotated locations for NP_001153874.1

    Status: VALIDATED

    Source sequence(s)
    AC087556, BC147727
    Consensus CDS
    CCDS49827.1
    UniProtKB/TrEMBL
    B2RWD4, E9Q9H8
    Related
    ENSMUSP00000110802.3, ENSMUST00000115149.3
    Conserved Domains (1) summary
    pfam05805
    Location:10 → 204
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32218823..32227397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522217.3 → XP_006522280.1  transmembrane 4 L6 family member 19 isoform X1

    UniProtKB/TrEMBL
    B2RWD4
    Conserved Domains (1) summary
    pfam05805
    Location:31 → 225
    L6_membrane; L6 membrane protein

  2. XM_006522221.4 → XP_006522284.1  transmembrane 4 L6 family member 19 isoform X2

    See identical proteins and their annotated locations for XP_006522284.1

    UniProtKB/TrEMBL
    B2RWD4, E9Q9H8
    Conserved Domains (1) summary
    pfam05805
    Location:10 → 204
    L6_membrane; L6 membrane protein

  3. XM_006522222.3 → XP_006522285.1  transmembrane 4 L6 family member 19 isoform X3

    Conserved Domains (1) summary
    pfam05805
    Location:31 → 100
    L6_membrane; L6 membrane protein
Nucleotide Protein Strain
Heading Accession and Version

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