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CG7369 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768961, updated on 2-Nov-2024

Summary

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Official Symbol
CG7369provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037188
Locus tag
Dmel_CG7369
See related
AllianceGenome:FB:FBgn0037188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7369
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; ganglia; and pole plasm. Orthologous to several human genes including RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG7369 in Genome Data Viewer
Location:
80A1-80A1; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22741793..22748614)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22734893..22741714)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45163 Neighboring gene uncharacterized protein Neighboring gene lethal (3) 04053 Neighboring gene long non-coding RNA:CR45961 Neighboring gene Secretory Pathway Calcium atpase Neighboring gene uncharacterized protein Neighboring gene jim

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
  2. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
  3. The Landscape of the DNA Transposons in the Genome of the Horezu_LaPeri Strain of Drosophila melanogaster. Bologa AM, et al. Insects, 2023 May 25. PMID 37367310, Free PMC Article
  4. A functional genomic analysis of cell morphology using RNA interference. Kiger AA, et al. J Biol, 2003. PMID 14527345, Free PMC Article
  5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7369-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22741793..22748614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141158.4 → NP_649415.2  uncharacterized protein Dmel_CG7369 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649415.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTU3, Q8SYL9
    Conserved Domains (2) summary
    smart00147
    Location:388 → 649
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    pfam00618
    Location:116 → 261
    RasGEF_N; RasGEF N-terminal motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTU3 Q7KTU3

Gene LinkOut

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