mei-W68 meiotic W68 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mei-W68provided by FlyBase
Official Full Name: meiotic W68provided by FlyBase
Primary source: FLYBASE:FBgn0002716
Locus tag: Dmel_CG7753
See related: AllianceGenome:FB:FBgn0002716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG30132; CG7753; Dmel\CG7753; l(2)k05603; mei; mei W-68; mei-w68; Mei-w68; Mei-W68; meiW68; MeiW68; Spo-11; spo11; Spo11; SPO11; W68
Summary: Predicted to enable DNA binding activity. Involved in meiosis I cell cycle process and meiotic DNA double-strand break processing. Predicted to be located in chromosome. Predicted to be active in nuclear chromosome. Is expressed in several structures, including embryonic/larval anterior midgut; embryonic/larval fat body; germarium region 2; germarium region 3; and larval central nervous system. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19456170..19459523)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15343675..15347028)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info
involved_in early meiotic recombination nodule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late meiotic recombination nodule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA double-strand break formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA double-strand break processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA double-strand break processing	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte karyosome formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info

NP_995901.1

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