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Cyp12d1-d Cytochrome P450 12d1 distal [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768720, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp12d1-dprovided by FlyBase
Official Full Name
Cytochrome P450 12d1 distalprovided by FlyBase
Primary source
FLYBASE:FBgn0053503
Locus tag
Dmel_CG33503
See related
AllianceGenome:FB:FBgn0053503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12d1; 12D1; CG18239; CG18240; CG33503; CT26082; Cyp 12d1; CYP12A2; Cyp12d; cyp12d1; Cyp12d1; CYP12D1; cyp12d1-d; CYP12d1-d; Cyp12d2; Dmel\CG33503
Summary
Predicted to enable 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity. Involved in response to DDT. Predicted to be located in mitochondrion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic head; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Cyp12d1-d in Genome Data Viewer
Location:
47D4-47D4; 2-63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11123658..11125647, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7011163..7013152, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 12d1 proximal Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis. Mitchell CL, et al. PLoS One, 2014. PMID 24695618, Free PMC Article
  2. Xenobiotic response in Drosophila melanogaster: sex dependence of P450 and GST gene induction. Le Goff G, et al. Insect Biochem Mol Biol, 2006 Aug. PMID 16876710
  3. A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus. Li T, et al. Sci Rep, 2015 Dec 10. PMID 26656663, Free PMC Article
  4. Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance. Jones RT, et al. Pest Manag Sci, 2010 Oct. PMID 20583201
  5. Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus. Schmidt JM, et al. PLoS Genet, 2010 Jun 24. PMID 20585622, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to DDT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to insecticide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vitamin D catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome P450 12d1 distal
Names
CG33503-PA
Cyp12d1-d-PA
cytochrome P450
cytochrome P450-12d1
NP_995812.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11123658..11125647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206090.2 → NP_995812.1  cytochrome P450 12d1 distal [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNB6, Q7KR10, Q95RF5
    Conserved Domains (1) summary
    cl12078
    Location:70 → 508
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KR10.1 Q7KR10

Gene LinkOut

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