U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fer1 48 related 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768661, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Fer1provided by FlyBase
Official Full Name
48 related 1provided by FlyBase
Primary source
FLYBASE:FBgn0037475
Locus tag
Dmel_CG33323
See related
AllianceGenome:FB:FBgn0037475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH30329; bHLHa30; CG10066; CG14611; CG33323; Dmel\CG33323; fer1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Is expressed in several structures, including adult antennal olfactory receptor neurons; central brain primordium; embryonic foregut; embryonic stomatogastric nervous system; and ganglia. Human ortholog(s) of this gene implicated in pancreatic agenesis 1. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fer1 in Genome Data Viewer
Location:
84C5-84C6; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7136206..7141972)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2961928..2967694)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-TCC 1-2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR42738 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GST-containing FLYWCH zinc-finger protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit. Rudisill SS, et al. Biol Trace Elem Res, 2019 May. PMID 30022428, Free PMC Article
  2. Thermodynamic model of gene regulation for the Or59b olfactory receptor in Drosophila. González A, et al. PLoS Comput Biol, 2019 Jan. PMID 30653495, Free PMC Article
  3. Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila. Jafari S, et al. PLoS Genet, 2015 Mar. PMID 25760344, Free PMC Article
  4. Metal ions in insect reproduction: a crosstalk between reproductive physiology and immunity. Cardoso-Jaime V, et al. Curr Opin Insect Sci, 2022 Aug. PMID 35483647, Free PMC Article
  5. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 7140147-7141062 mobile_element_type = transposon:HB{}1242

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in developmental process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
48 related 1
Names
CG33323-PA
CG33323-PB
Fer1-PA
Fer1-PB
ferritin 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7136206..7141972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275405.1 → NP_001262334.1  48 related 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262334.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFD8
    Conserved Domains (1) summary
    smart00353
    Location:92 → 144
    HLH; helix loop helix domain

  2. NM_206455.3 → NP_996177.1  48 related 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996177.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXF5, Q9VI67
    Conserved Domains (1) summary
    cd11417
    Location:82 → 137
    bHLH_TS_PTF1A; basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFD8 A0A0B4KFD8
Q9VI67 Q9VI67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools