U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UBE2S ubiquitin conjugating enzyme E2 S [ Homo sapiens (human) ]

Gene ID: 27338, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
UBE2Sprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Sprovided by HGNC
Primary source
HGNC:HGNC:17895
See related
Ensembl:ENSG00000108106 MIM:610309; AllianceGenome:HGNC:17895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPF5; E2EPF; E2-EPF
Summary
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55399745..55407788, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58495197..58503241, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55911113..55919156, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55890663-55891163 Neighboring gene transmembrane protein 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55895260-55896222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15093 Neighboring gene ribosomal protein L28 Neighboring gene microRNA 6805 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55915190-55915690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55915691-55916191 Neighboring gene small nucleolar RNA, C/D box 157 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:55918619-55919132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11031 Neighboring gene Sharpr-MPRA regulatory region 8373 Neighboring gene uncharacterized LOC105372462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55930479-55931048 Neighboring gene MPRA-validated peak3567 silencer Neighboring gene shisa family member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55953359-55953987

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway. Zhao R, et al. Exp Cell Res, 2022 Oct 1. PMID 35863455
  2. UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis. Zhang M, et al. Mol Med, 2022 Jun 3. PMID 35658829, Free PMC Article
  3. UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway. Hu W, et al. J Ovarian Res, 2021 Sep 17. PMID 34535173, Free PMC Article
  4. Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development. Wang P, et al. J Invest Dermatol, 2021 Feb. PMID 32603752
  5. Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer. Qin Y, et al. Int J Med Sci, 2020. PMID 32038111, Free PMC Article

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration.
    Title: As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration.
  2. UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
    Title: UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
  3. Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway.
    Title: Knockout of UBE2S inhibits the proliferation of gastric cancer cells and induces apoptosis by FAS-mediated death receptor pathway.
  4. UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis.
    Title: UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis.
  5. UBE2S as a novel ubiquitinated regulator of p16 and beta-catenin to promote bone metastasis of prostate cancer.
    Title: UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer.
  6. UBE2S activates NF-kappaB signaling by binding with IkappaBalpha and promotes metastasis of lung adenocarcinoma cells.
    Title: UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells.
  7. UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
    Title: UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development.
  8. Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
    Title: Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.
  9. UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
    Title: UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
  10. UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/beta-catenin signaling pathway.
    Title: UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables anaphase-promoting complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in exit from mitosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in free ubiquitin chain polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K27-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K29-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K6-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin-conjugating enzyme E2 S
Names
E2 ubiquitin-conjugating enzyme S
E2-EPF5
ubiquitin carrier protein S
ubiquitin conjugating enzyme E2S
ubiquitin-conjugating enzyme E2-24 kDa
ubiquitin-conjugating enzyme E2-EPF5
ubiquitin-protein ligase S
NP_055316.2
XP_011525054.1
XP_054176554.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014501.3 → NP_055316.2  ubiquitin-conjugating enzyme E2 S

    See identical proteins and their annotated locations for NP_055316.2

    Status: REVIEWED

    Source sequence(s)
    AC020922, BC065364, CA421746, CN305224
    Consensus CDS
    CCDS33114.1
    UniProtKB/Swiss-Prot
    Q16763, Q9BTC1
    UniProtKB/TrEMBL
    Q2QD04, Q6NXQ4
    Related
    ENSP00000264552.8, ENST00000264552.14
    Conserved Domains (1) summary
    pfam00179
    Location:16 → 152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55399745..55407788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526752.3 → XP_011525054.1  ubiquitin-conjugating enzyme E2 S isoform X1

    Conserved Domains (1) summary
    pfam00179
    Location:16 → 114
    UQ_con; Ubiquitin-conjugating enzyme

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58495197..58503241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320579.1 → XP_054176554.1  ubiquitin-conjugating enzyme E2 S isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16763.2 GenPept UniProtKB/Swiss-Prot:Q16763

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous