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Plaat1 phospholipase A and acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 27281, updated on 2-Nov-2024

Summary

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Official Symbol
Plaat1provided by MGI
Official Full Name
phospholipase A and acyltransferase 1provided by MGI
Primary source
MGI:MGI:1351473
See related
Ensembl:ENSMUSG00000022525 AllianceGenome:MGI:1351473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A-C1; HRSL1; Hrasls; Hrasrs; 2810012B06Rik
Summary
Enables phospholipase activity. Acts upstream of or within ether lipid metabolic process and peroxisome organization. Located in nuclear envelope lumen and peroxisome. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 44.5), heart adult (RPKM 3.7) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Plaat1 in Genome Data Viewer
Location:
16 B2; 16 20.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (29027883..29049283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (29209133..29230531)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_40518 Neighboring gene STARR-seq mESC enhancer starr_40520 Neighboring gene predicted gene 8253 Neighboring gene STARR-seq mESC enhancer starr_40521 Neighboring gene ATPase type 13A5 Neighboring gene STARR-seq mESC enhancer starr_40522 Neighboring gene STARR-seq mESC enhancer starr_40523 Neighboring gene ATPase type 13A4 Neighboring gene zinc finger protein 788 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:29579308-29579525 Neighboring gene STARR-seq mESC enhancer starr_40527 Neighboring gene OPA1, mitochondrial dynamin like GTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity. Bradley RM, et al. Int J Mol Sci, 2022 Jun 16. PMID 35743156, Free PMC Article
  2. PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice. Rahman SMK, et al. FASEB J, 2023 Jul. PMID 37330992
  3. Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice. Hussain Z, et al. J Lipid Res, 2016 Nov. PMID 27623847, Free PMC Article
  4. Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation. Uyama T, et al. Biochim Biophys Acta, 2013 Dec. PMID 23994608
  5. Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. Shinohara N, et al. J Lipid Res, 2011 Nov. PMID 21880860, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice.
    Title: PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice.
  2. PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity.
    Title: PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin Transacylase Activity.
  3. a possible enzyme activity of A-C1
    Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables N-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A1 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylphosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within ether lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organelle disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within peroxisome organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of cell growth TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phospholipase A and acyltransferase 1
Names
HRAS-like suppressor 1
Harvey rat sarcoma virus oncogene related suppressor
phospholipid-metabolizing enzyme A-C1
NP_001344021.1
NP_001348218.1
NP_038779.2
XP_017172511.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357092.2 → NP_001344021.1  phospholipase A and acyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC154421
    Consensus CDS
    CCDS28094.1
    UniProtKB/Swiss-Prot
    Q5D099, Q9D0S3, Q9QZU4
    UniProtKB/TrEMBL
    A0A0R4J130
    Related
    ENSMUSP00000123809.2, ENSMUST00000162747.8
    Conserved Domains (1) summary
    pfam04970
    Location:27 → 130
    LRAT; Lecithin retinol acyltransferase

  2. NM_001361289.2 → NP_001348218.1  phospholipase A and acyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC154421
    Consensus CDS
    CCDS28094.1
    UniProtKB/Swiss-Prot
    Q5D099, Q9D0S3, Q9QZU4
    UniProtKB/TrEMBL
    A0A0R4J130
    Conserved Domains (1) summary
    pfam04970
    Location:27 → 130
    LRAT; Lecithin retinol acyltransferase

  3. NM_013751.7 → NP_038779.2  phospholipase A and acyltransferase 1

    See identical proteins and their annotated locations for NP_038779.2

    Status: VALIDATED

    Source sequence(s)
    AC154421
    Consensus CDS
    CCDS28094.1
    UniProtKB/Swiss-Prot
    Q5D099, Q9D0S3, Q9QZU4
    UniProtKB/TrEMBL
    A0A0R4J130
    Related
    ENSMUSP00000087257.5, ENSMUST00000089824.11
    Conserved Domains (1) summary
    pfam04970
    Location:27 → 130
    LRAT; Lecithin retinol acyltransferase

RNA

  1. NR_154594.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154421

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    29027883..29049283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317022.3 → XP_017172511.1  phospholipase A and acyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5D099, Q9D0S3, Q9QZU4
    UniProtKB/TrEMBL
    A0A0R4J130
    Conserved Domains (1) summary
    pfam04970
    Location:27 → 130
    LRAT; Lecithin retinol acyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZU4.1 GenPept UniProtKB/Swiss-Prot:Q9QZU4

Gene LinkOut

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