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Syn3 synapsin III [ Mus musculus (house mouse) ]

Gene ID: 27204, updated on 2-Nov-2024

Summary

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Official Symbol
Syn3provided by MGI
Official Full Name
synapsin IIIprovided by MGI
Primary source
MGI:MGI:1351334
See related
Ensembl:ENSMUSG00000059602 AllianceGenome:MGI:1351334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP binding activity. Involved in synaptic vesicle clustering. Located in postsynaptic density and synaptic vesicle membrane. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skeletal muscle. Used to study autism spectrum disorder and epilepsy. Orthologous to human SYN3 (synapsin III). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 3.6), whole brain E14.5 (RPKM 2.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Syn3 in Genome Data Viewer
Location:
10 C1; 10 41.95 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (85884610..86336730, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86048746..86498926, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27455 Neighboring gene BPI fold containing family C Neighboring gene STARR-positive B cell enhancer ABC_E8355 Neighboring gene F-box protein 7 Neighboring gene predicted gene, 24430 Neighboring gene RIKEN cDNA 4930486F22 gene Neighboring gene STARR-seq mESC enhancer starr_27456 Neighboring gene predicted gene, 51812 Neighboring gene STARR-seq mESC enhancer starr_27457 Neighboring gene STARR-seq mESC enhancer starr_27458 Neighboring gene predicted gene, 35636 Neighboring gene STARR-seq mESC enhancer starr_27459 Neighboring gene VISTA enhancer mm52 Neighboring gene predicted gene, 57766 Neighboring gene tissue inhibitor of metalloproteinase 3 Neighboring gene STARR-seq mESC enhancer starr_27465 Neighboring gene predicted gene 6729 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation. Piccini A, et al. J Neurosci, 2015 Sep 23. PMID 26400944, Free PMC Article
  2. Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. Kao HT, et al. J Comp Neurol, 2008 Apr 20. PMID 18271024
  3. Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. Porton B, et al. Genes Brain Behav, 2010 Apr. PMID 20050925, Free PMC Article
  4. Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype. Faustini G, et al. Mol Ther, 2022 Apr 6. PMID 35038583, Free PMC Article
  5. Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance. Moore A, et al. eNeuro, 2021 Sep-Oct. PMID 34413083, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLCgamma1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
    Title: PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
  2. Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.
    Title: Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.
  3. Syn III constitutes a crucial mediator of alpha-synuclein aggregation and toxicity and identify Syn III as a novel therapeutic target for Parkinson's disease
    Title: Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.
  4. This study demonstrated that synapsin 3 regulating GABA Release from Hippocampal Interneurons.
    Title: Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons.
  5. These findings support a reciprocal modulatory interaction of alpha-syn and synapsin III in the regulation of dopamine neuron synaptic function.
    Title: α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
  6. The results of this study show SynIII plays a central role in early stages of neuronal development involving phosphorylation-dependent neuronal survival, polarization, and neuritic growth
    Title: Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
  7. This study demonostrated that Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex.
    Title: Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex.
  8. Behavioral and neurophysiological features of Syn3 knockout mice are characterized by observation of the development and progress of seizures from postnatal day 20 to 180.
    Title: Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice.
  9. Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns.
    Title: Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
  10. Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear
    Title: Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130403

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle clustering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
synapsin-3
Names
synapsin IIIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164495.1 → NP_001157967.1  synapsin-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125060, AK043854, AK084032
    Consensus CDS
    CCDS48659.1
    UniProtKB/TrEMBL
    D3Z620
    Related
    ENSMUSP00000113408.2, ENSMUST00000121789.2
    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 236
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. NM_013722.3 → NP_038750.2  synapsin-3 isoform 1

    See identical proteins and their annotated locations for NP_038750.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122919, AK043854, AK080557, BC059894, BC107397
    Consensus CDS
    CCDS24096.1
    UniProtKB/Swiss-Prot
    E9QNQ6, Q8JZP2
    UniProtKB/TrEMBL
    Q3KN99, Q9QZA3
    Related
    ENSMUSP00000113720.2, ENSMUST00000120638.8
    Conserved Domains (4) summary
    pfam02750
    Location:192 → 394
    Synapsin_C; Synapsin, ATP binding domain
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam09770
    Location:400 → 534
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    85884610..86336730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513698.4 → XP_006513761.1  synapsin-3 isoform X1

    See identical proteins and their annotated locations for XP_006513761.1

    UniProtKB/Swiss-Prot
    E9QNQ6, Q8JZP2
    UniProtKB/TrEMBL
    Q3KN99, Q9QZA3
    Conserved Domains (4) summary
    pfam02750
    Location:192 → 394
    Synapsin_C; Synapsin, ATP binding domain
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam09770
    Location:400 → 534
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal

  2. XM_006513699.5 → XP_006513762.1  synapsin-3 isoform X1

    See identical proteins and their annotated locations for XP_006513762.1

    UniProtKB/Swiss-Prot
    E9QNQ6, Q8JZP2
    UniProtKB/TrEMBL
    Q3KN99, Q9QZA3
    Conserved Domains (4) summary
    pfam02750
    Location:192 → 394
    Synapsin_C; Synapsin, ATP binding domain
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam09770
    Location:400 → 534
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal

  3. XM_006513700.5 → XP_006513763.1  synapsin-3 isoform X1

    See identical proteins and their annotated locations for XP_006513763.1

    UniProtKB/Swiss-Prot
    E9QNQ6, Q8JZP2
    UniProtKB/TrEMBL
    Q3KN99, Q9QZA3
    Conserved Domains (4) summary
    pfam02750
    Location:192 → 394
    Synapsin_C; Synapsin, ATP binding domain
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam09770
    Location:400 → 534
    PAT1; Topoisomerase II-associated protein PAT1
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal

  4. XM_030245098.2 → XP_030100958.1  synapsin-3 isoform X2

    Conserved Domains (3) summary
    pfam02078
    Location:90 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 307
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  5. XM_036155797.1 → XP_036011690.1  synapsin-3 isoform X2

    Conserved Domains (3) summary
    pfam02078
    Location:90 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 307
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  6. XM_030245101.2 → XP_030100961.1  synapsin-3 isoform X5

    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 257
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  7. XM_030245100.2 → XP_030100960.1  synapsin-3 isoform X4

    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 236
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  8. XM_030245103.2 → XP_030100963.1  synapsin-3 isoform X7

    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 236
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  9. XM_030245099.2 → XP_030100959.1  synapsin-3 isoform X3

    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 236
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  10. XM_030245102.2 → XP_030100962.1  synapsin-3 isoform X6

    UniProtKB/TrEMBL
    D3Z620
    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 236
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  11. XM_030245104.2 → XP_030100964.1  synapsin-3 isoform X8

    Conserved Domains (3) summary
    pfam02078
    Location:93 → 190
    Synapsin; N-terminal domain
    pfam10581
    Location:1 → 29
    Synapsin_N; Synapsin N-terminal
    cl17255
    Location:192 → 239
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZP2.2 GenPept UniProtKB/Swiss-Prot:Q8JZP2

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