U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IL17B interleukin 17B [ Homo sapiens (human) ]

Gene ID: 27190, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
IL17Bprovided by HGNC
Official Full Name
interleukin 17Bprovided by HGNC
Primary source
HGNC:HGNC:5982
See related
Ensembl:ENSG00000127743 MIM:604627; AllianceGenome:HGNC:5982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIRF; IL-20; IL-17B; ZCYTO7
Summary
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IL17B in Genome Data Viewer
Location:
5q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (149374267..149404202, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (149909114..149939047, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148753830..148783765, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene GRPEL2 antisense RNA 1 Neighboring gene GrpE like 2, mitochondrial Neighboring gene Sharpr-MPRA regulatory region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16496 Neighboring gene prenylcysteine oxidase 1 like Neighboring gene Sharpr-MPRA regulatory region 12528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148746417-148747281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148747282-148748145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148759103-148759637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148759990-148760702 Neighboring gene uncharacterized LOC101927046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148762129-148762840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148764726-148765226 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148784456-148785046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148786897-148787897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148790014-148790554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148790555-148791094 Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82102 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82107 Neighboring gene VISTA enhancer hs1752 Neighboring gene microRNA 143 Neighboring gene microRNA 145

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes. Ramirez-Carrozzi V, et al. J Immunol, 2019 Apr 1. PMID 30770417
  2. IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells. Bie Q, et al. Oncotarget, 2017 Mar 21. PMID 28145881, Free PMC Article
  3. Neutrophils produce interleukin-17B in rheumatoid synovial tissue. Kouri VP, et al. Rheumatology (Oxford), 2014 Jan. PMID 24056520
  4. [Eukaryotic expression and biological activity of recombinant human IL-17B protein]. Liu GQ, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012 Mar. PMID 22394632
  5. Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis. Husein-ElAhmed H, et al. J Eur Acad Dermatol Venereol, 2022 Oct. PMID 35570406

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.
    Title: Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda.
  2. Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis.
    Title: Potential role of INTERLEUKIN-17 in the pathogenesis of oral lichen planus: a systematic review with META-analysis.
  3. Our data reveal that analogous to other IL-17 family members, IL-17B has an inflammatory role in the human system.
    Title: Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.
  4. Gene expression microarray analysis followed by Kaplan-Meier survival curve showed that high expression level of IL-17B was associated with poor survival of patients with lung neoplasm.
    Title: A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis.
  5. The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells.
    Title: Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.
  6. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells.
    Title: IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells.
  7. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family
    Title: Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing.
  8. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW}
    Title: The role of IL17B-IL17RB signaling pathway in breast cancer.
  9. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy.
    Title: Targeting interleukin-17 receptors.
  10. IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy.
    Title: Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC138900, MGC138901

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-17B
Names
cytokine-like protein ZCYTO7
interleukin 20
interleukin-17 beta
neuronal interleukin-17 related factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317987.2 → NP_001304916.1  interleukin-17B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC131025, AF212311, BM826445
    UniProtKB/Swiss-Prot
    Q9UHF5
    Related
    ENST00000505432.1
    Conserved Domains (1) summary
    pfam06083
    Location:44 → 127
    IL17; Interleukin-17

  2. NM_014443.3 → NP_055258.1  interleukin-17B isoform 1 precursor

    See identical proteins and their annotated locations for NP_055258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC131025
    Consensus CDS
    CCDS4297.1
    UniProtKB/Swiss-Prot
    Q14CE5, Q9UHF5
    UniProtKB/TrEMBL
    Q6IAG3
    Related
    ENSP00000261796.3, ENST00000261796.4
    Conserved Domains (1) summary
    pfam06083
    Location:96 → 179
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    149374267..149404202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009348.2 → XP_016864837.1  interleukin-17B isoform X2

    Conserved Domains (1) summary
    pfam06083
    Location:44 → 127
    IL17; Interleukin-17

  2. XM_017009347.2 → XP_016864836.1  interleukin-17B isoform X2

    Conserved Domains (1) summary
    pfam06083
    Location:44 → 127
    IL17; Interleukin-17

  3. XM_047417104.1 → XP_047273060.1  interleukin-17B isoform X2

  4. XM_017009346.2 → XP_016864835.1  interleukin-17B isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    149909114..149939047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352390.1 → XP_054208365.1  interleukin-17B isoform X2

  2. XM_054352389.1 → XP_054208364.1  interleukin-17B isoform X2

  3. XM_054352391.1 → XP_054208366.1  interleukin-17B isoform X2

  4. XM_054352388.1 → XP_054208363.1  interleukin-17B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHF5.1 GenPept UniProtKB/Swiss-Prot:Q9UHF5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous