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Shc4 SHC (Src homology 2 domain containing) family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 271849, updated on 28-Oct-2024

Summary

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Official Symbol
Shc4provided by MGI
Official Full Name
SHC (Src homology 2 domain containing) family, member 4provided by MGI
Primary source
MGI:MGI:2655364
See related
Ensembl:ENSMUSG00000035109 AllianceGenome:MGI:2655364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RaLP; Gm685; 6230417E10Rik; 9930029B02Rik
Summary
Enables protein domain specific binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and skin. Orthologous to human SHC4 (SHC adaptor protein 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in genital fat pad adult (RPKM 3.4), testis adult (RPKM 2.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Shc4 in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125469359..125566085, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125627439..125724148, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05588 Neighboring gene fibrillin 1 Neighboring gene STARR-seq mESC enhancer starr_05589 Neighboring gene centrosomal protein 152 Neighboring gene STARR-positive B cell enhancer ABC_E1254 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9530 Neighboring gene STARR-seq mESC enhancer starr_05593 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125550365-125550474 Neighboring gene predicted gene, 35231 Neighboring gene STARR-positive B cell enhancer ABC_E11155 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene SECIS binding protein 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125602741-125602942 Neighboring gene STARR-positive B cell enhancer ABC_E5976 Neighboring gene STARR-positive B cell enhancer ABC_E7857 Neighboring gene STARR-positive B cell enhancer ABC_E11156 Neighboring gene COP9 signalosome subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells. Ahmed SBM, et al. Int J Biochem Cell Biol, 2019 Jul. PMID 31121283
  2. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. Fagiani E, et al. Cancer Res, 2007 Apr 1. PMID 17409413
  3. Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development. Hawley SP, et al. Dev Dyn, 2011 Jan. PMID 21117147
  4. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. Jones N, et al. Mol Cell Biol, 2007 Jul. PMID 17452444, Free PMC Article
  5. Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein. Turco MY, et al. Stem Cells, 2012 Nov. PMID 22948967, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data also showed that the death signalling initiated by the ShcD/ERK interaction was accompanied by p21 phosphorylation. In summary, these data identified ShcD, via its interaction with ERK, as a proapoptotic protein under oxidative stress conditions.
    Title: Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells.
  2. Shc4 is an important modulator in the switch of key pathway(s) involved in determining epiblast stem cell identity.
    Title: Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein.
  3. The unique tissue distribution patterns of Shc proteins likely contribute to their complex tissue-specific signaling functions during embryogenesis.
    Title: Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.
  4. A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor.
    Title: Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SHC-transforming protein 4
Names
SH2 domain protein C4
SHC-transforming protein D
mShcD
novel phosphotyrosine interaction domain (PTB/PID) and SH2 domains containing protein
rai-like protein RaLP
src homology 2 domain-containing-transforming protein C4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199022.3 → NP_950187.1  SHC-transforming protein 4

    See identical proteins and their annotated locations for NP_950187.1

    Status: VALIDATED

    Source sequence(s)
    AL844580, AL929166
    Consensus CDS
    CCDS16678.1
    UniProtKB/Swiss-Prot
    Q6S5L9
    Related
    ENSMUSP00000043146.8, ENSMUST00000042246.14
    Conserved Domains (2) summary
    cd09925
    Location:513 → 614
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:181 → 347
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125469359..125566085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162265.1 → XP_036018158.1  SHC-transforming protein 4 isoform X2

    UniProtKB/TrEMBL
    A2AUN0
    Related
    ENSMUSP00000106106.2, ENSMUST00000110480.8
    Conserved Domains (2) summary
    cd09925
    Location:227 → 328
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cl17171
    Location:1 → 61
    PH-like; Pleckstrin homology-like domain

  2. XM_006499655.5 → XP_006499718.3  SHC-transforming protein 4 isoform X1

    Conserved Domains (2) summary
    cd09925
    Location:297 → 398
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cl17171
    Location:63 → 131
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6S5L9.1 GenPept UniProtKB/Swiss-Prot:Q6S5L9

Gene LinkOut

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